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Rabbit Anti-MATR3 Recombinant Antibody (CBFYM-0299) (CBMAB-M0364-FY)

This product is rabbit antibody that recognizes MATR3. The antibody CBFYM-0299 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all MATR3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBFYM-0299
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MATRIN 3
Introduction
This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X.
Entrez Gene ID
Human9782
Mouse17184
Rat29150
UniProt ID
HumanP43243
MouseQ8K310
RatP43244
Alternative Names
Matrin 3; Vocal Cord And Pharyngeal Weakness With Distal Myopathy; Myopathy, Distal 2; Matrin-3; KIAA0723; ALS21; VCPDM; MPD2
Function
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947).

May bind to specific miRNA hairpins (PubMed:28431233).
Biological Process
Activation of innate immune response Source: UniProtKB
Heart valve development Source: BHF-UCL
Innate immune response Source: UniProtKB-KW
Posttranscriptional regulation of gene expression Source: CACAO
Ventricular septum development Source: BHF-UCL
Cellular Location
Nucleus matrix
Involvement in disease
Amyotrophic lateral sclerosis 21 (ALS21):
A neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia.

Lin, Z., Zhao, S., Li, X., Miao, Z., Cao, J., Chen, Y., ... & Ji, Y. (2023). Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis. Cell Research, 1-16.

Durślewicz, J., Klimaszewska-Wiśniewska, A., Antosik, P., & Grzanka, D. (2023). Low expression of MATR3 is associated with poor survival in clear cell renal cell carcinoma. Biomedicines, 11(2), 326.

Zeng, X., Lei, Y., Pan, S., Sun, J., He, H., Xiao, D., ... & Zhang, Q. (2023). LncRNA15691 promotes T-ALL infiltration by upregulating CCR9 via increased MATR3 stability. Journal of Leukocyte Biology, 113(2), 203-215.

Durślewicz, J., Klimaszewska-Wiśniewska, A., Jóźwicki, J., Antosik, P., Kozerawski, K., Grzanka, D., & Braun, M. (2022). Prognostic significance of MATR3 in stage I and II non-small cell lung cancer patients. Journal of Cancer Research and Clinical Oncology, 148(12), 3313-3322.

Sun, Z., Chen, W., Wang, Z., Wang, S., Zan, J., Zheng, L., & Zhao, W. (2022). Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis. Clinical Immunology, 245, 109176.

Desideri, F., Cipriano, A., Petrezselyova, S., Buonaiuto, G., Santini, T., Kasparek, P., ... & Ballarino, M. (2020). Intronic determinants coordinate charme lncRNA nuclear activity through the interaction with MATR3 and PTBP1. Cell Reports, 33(12).

Kao, C. S., van Bruggen, R., Kim, J. R., Chen, X. X. L., Chan, C., Lee, J., ... & Park, J. (2020). Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nature Communications, 11(1), 5304.

Weiss, K., Treiber, T., Meister, G., & Schratt, G. (2019). The nuclear matrix protein Matr3 regulates processing of the synaptic microRNA-138-5p. Neurobiology of learning and memory, 159, 36-45.

Zhang, X., Yamashita, S., Hara, K., Doki, T., Tawara, N., Ikeda, T., ... & Ando, Y. (2019). A mutant MATR3 mouse model to explain multisystem proteinopathy. The Journal of pathology, 249(2), 182-192.

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For research use only. Not intended for any clinical use.

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