Human MATR3 ELISA Kit (V2LY-0626-LY4864)

Name: Human MATR3 ELISA Kit
SKU: V2LY-0626-LY4864
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0077 ng/mL

Detection Range

0.015-3 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

94.6 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

MATRIN 3

Function

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947).

May bind to specific miRNA hairpins (PubMed:28431233).

Biological Process

Activation of innate immune response Source: UniProtKB
Heart valve development Source: BHF-UCL
Innate immune response Source: UniProtKB-KW
Posttranscriptional regulation of gene expression Source: CACAO
Ventricular septum development Source: BHF-UCL

Cellular Location

Nucleus matrix

Involvement in disease

Amyotrophic lateral sclerosis 21 (ALS21):
A neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia.

Lin, Z., Zhao, S., Li, X., Miao, Z., Cao, J., Chen, Y., ... & Ji, Y. (2023). Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis. Cell Research, 1-16.

Durślewicz, J., Klimaszewska-Wiśniewska, A., Antosik, P., & Grzanka, D. (2023). Low expression of MATR3 is associated with poor survival in clear cell renal cell carcinoma. Biomedicines, 11(2), 326.

Zeng, X., Lei, Y., Pan, S., Sun, J., He, H., Xiao, D., ... & Zhang, Q. (2023). LncRNA15691 promotes T-ALL infiltration by upregulating CCR9 via increased MATR3 stability. Journal of Leukocyte Biology, 113(2), 203-215.

Durślewicz, J., Klimaszewska-Wiśniewska, A., Jóźwicki, J., Antosik, P., Kozerawski, K., Grzanka, D., & Braun, M. (2022). Prognostic significance of MATR3 in stage I and II non-small cell lung cancer patients. Journal of Cancer Research and Clinical Oncology, 148(12), 3313-3322.

Sun, Z., Chen, W., Wang, Z., Wang, S., Zan, J., Zheng, L., & Zhao, W. (2022). Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis. Clinical Immunology, 245, 109176.

Desideri, F., Cipriano, A., Petrezselyova, S., Buonaiuto, G., Santini, T., Kasparek, P., ... & Ballarino, M. (2020). Intronic determinants coordinate charme lncRNA nuclear activity through the interaction with MATR3 and PTBP1. Cell Reports, 33(12).

Kao, C. S., van Bruggen, R., Kim, J. R., Chen, X. X. L., Chan, C., Lee, J., ... & Park, J. (2020). Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nature Communications, 11(1), 5304.

Weiss, K., Treiber, T., Meister, G., & Schratt, G. (2019). The nuclear matrix protein Matr3 regulates processing of the synaptic microRNA-138-5p. Neurobiology of learning and memory, 159, 36-45.

Zhang, X., Yamashita, S., Hara, K., Doki, T., Tawara, N., Ikeda, T., ... & Ando, Y. (2019). A mutant MATR3 mouse model to explain multisystem proteinopathy. The Journal of pathology, 249(2), 182-192.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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