Mouse Anti-MATR3 Recombinant Antibody (CBFYM-1770) (CBMAB-M1938-FY)

Name: Mouse Anti-MATR3 Recombinant Antibody (CBFYM-1770)
SKU: CBMAB-M1938-FY
Rating: 5 (1 reviews)

See all MATR3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1770

Application

Dot, ICC, WB

Immunogen

Recombinant sequence from human Matrin 3

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MATRIN 3

Introduction

This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X.

Entrez Gene ID

Human	9782
Mouse	17184
Rat	29150

UniProt ID

Human	P43243
Mouse	Q8K310
Rat	P43244

Alternative Names

Matrin 3; Vocal Cord And Pharyngeal Weakness With Distal Myopathy; Myopathy, Distal 2; Matrin-3; KIAA0723; ALS21; VCPDM; MPD2

Function

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947).

May bind to specific miRNA hairpins (PubMed:28431233).

Biological Process

Activation of innate immune response Source: UniProtKB
Heart valve development Source: BHF-UCL
Innate immune response Source: UniProtKB-KW
Posttranscriptional regulation of gene expression Source: CACAO
Ventricular septum development Source: BHF-UCL

Cellular Location

Nucleus matrix

Involvement in disease

Amyotrophic lateral sclerosis 21 (ALS21):
A neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia.

Lin, Z., Zhao, S., Li, X., Miao, Z., Cao, J., Chen, Y., ... & Ji, Y. (2023). Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis. Cell Research, 1-16.

Durślewicz, J., Klimaszewska-Wiśniewska, A., Antosik, P., & Grzanka, D. (2023). Low expression of MATR3 is associated with poor survival in clear cell renal cell carcinoma. Biomedicines, 11(2), 326.

Zeng, X., Lei, Y., Pan, S., Sun, J., He, H., Xiao, D., ... & Zhang, Q. (2023). LncRNA15691 promotes T-ALL infiltration by upregulating CCR9 via increased MATR3 stability. Journal of Leukocyte Biology, 113(2), 203-215.

Durślewicz, J., Klimaszewska-Wiśniewska, A., Jóźwicki, J., Antosik, P., Kozerawski, K., Grzanka, D., & Braun, M. (2022). Prognostic significance of MATR3 in stage I and II non-small cell lung cancer patients. Journal of Cancer Research and Clinical Oncology, 148(12), 3313-3322.

Sun, Z., Chen, W., Wang, Z., Wang, S., Zan, J., Zheng, L., & Zhao, W. (2022). Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis. Clinical Immunology, 245, 109176.

Desideri, F., Cipriano, A., Petrezselyova, S., Buonaiuto, G., Santini, T., Kasparek, P., ... & Ballarino, M. (2020). Intronic determinants coordinate charme lncRNA nuclear activity through the interaction with MATR3 and PTBP1. Cell Reports, 33(12).

Kao, C. S., van Bruggen, R., Kim, J. R., Chen, X. X. L., Chan, C., Lee, J., ... & Park, J. (2020). Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nature Communications, 11(1), 5304.

Weiss, K., Treiber, T., Meister, G., & Schratt, G. (2019). The nuclear matrix protein Matr3 regulates processing of the synaptic microRNA-138-5p. Neurobiology of learning and memory, 159, 36-45.

Zhang, X., Yamashita, S., Hara, K., Doki, T., Tawara, N., Ikeda, T., ... & Ando, Y. (2019). A mutant MATR3 mouse model to explain multisystem proteinopathy. The Journal of pathology, 249(2), 182-192.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-MATR3 Recombinant Antibody (CBFYM-1770)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-MATR3 Recombinant Antibody (CBFYM-0299) (CAT#: CBMAB-M0364-FY)

Mouse Anti-MATR3 Recombinant Antibody (CBFYM-1769) (CAT#: CBMAB-M1937-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry