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Mouse Anti-MAX Recombinant Antibody (4E10-1A9) (CBMAB-A5317-LY)

The product is antibody recognizes MAX. The antibody 4E10-1A9 immunoassay techniques such as: WB, ELISA.
See all MAX antibodies
Published Data
Fig.1 MAX expression modulates genes associated with proliferation and differentiation.
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Fig.2 Detection of MAX by immunohistochemistry with a MAX C-terminus–specific antibody.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E10-1A9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MAX (AAH03525, 1 a.a. ~ 151 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MAX
Introduction
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown. [provided by RefSeq]
Entrez Gene ID
4149
UniProt ID
P61244
Alternative Names
MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; orf1
Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Biological Process
Cellular response to peptide hormone stimulus Source: Ensembl
Cellular response to starvation Source: Ensembl
Negative regulation of gene expression Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Neuron apoptotic process Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Protein-containing complex assembly Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to axon injury Source: Ensembl
Response to insulin Source: Ensembl
Retina development in camera-type eye Source: Ensembl
Cellular Location
Nucleus
Other locations
dendrite
Involvement in disease
Pheochromocytoma (PCC):
A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
PTM
Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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