Mouse Anti-MAX Recombinant Antibody (CBFYM-1773) (CBMAB-M1941-FY)

Name: Mouse Anti-MAX Recombinant Antibody (CBFYM-1773)
SKU: CBMAB-M1941-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1773

Application

Dot

Immunogen

Recombinant Human Helix-Loop-Helix Zipper Protein (Max)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MAX

Introduction

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

4149

UniProt ID

P61244

Alternative Names

MYC Associated Factor X; Class D Basic Helix-Loop-Helix Protein 4; BHLHd4; Myc-Associated Factor X; MAX Protein; Protein Max

Function

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.

Biological Process

Cellular response to peptide hormone stimulus Source: Ensembl
Cellular response to starvation Source: Ensembl
Negative regulation of gene expression Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Neuron apoptotic process Source: Ensembl
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Protein-containing complex assembly Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to axon injury Source: Ensembl
Response to insulin Source: Ensembl
Retina development in camera-type eye Source: Ensembl

Cellular Location

Nucleus
Other locations
dendrite

Involvement in disease

Pheochromocytoma (PCC):
A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.

PTM

Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.

Holmes, A. G., Parker, J. B., Sagar, V., Truica, M. I., Soni, P. N., Han, H., ... & Chakravarti, D. (2022). A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression. Science Advances, 8(17), eabh3635.

Lafita-Navarro, M. C., Liaño-Pons, J., Quintanilla, A., Varela, I., Blanco, R., Ourique, F., ... & León, J. (2020). The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells. Journal of Biological Chemistry, 295(7), 2001-2017.

Li, K., Wang, F., Yang, Z. N., Zhang, T. T., Yuan, Y. F., Zhao, C. X., ... & Hu, Z. W. (2020). TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation. Nature Communications, 11(1), 6316.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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