Rat Anti-MC3R Recombinant Antibody (CBFYM-0126) (CBMAB-M0146-FY)

Name: Rat Anti-MC3R Recombinant Antibody (CBFYM-0126)
SKU: CBMAB-M0146-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYM-0126

Application

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MELANOCORTIN 3 RECEPTOR

Introduction

This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.

Entrez Gene ID

17201

UniProt ID

P33033

Alternative Names

Melanocortin 3 Receptor; MC3-R; Obesity Quantitative Trait Locus; Melanocortin Receptor 3; BMIQ9; OB20; OQTL; MC3

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Circadian regulation of gene expression Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Homoiothermy Source: Ensembl
Locomotor rhythm Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of blood pressure Source: Ensembl
Regulation of feeding behavior Source: Ensembl
Regulation of heart rate Source: Ensembl
Regulation of metabolic process Source: GO_Central
Sodium ion homeostasis Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-37
Helical: 38-63
Cytoplasmic: 64-75
Helical: 76-100
Extracellular: 101-118
Helical: 119-140
Cytoplasmic: 141-160
Helical: 161-181
Extracellular: 182-186
Helical: 187-210
Cytoplasmic: 211-245
Helical: 246-268
Extracellular: 269-277
Helical: 278-301
Cytoplasmic: 302-323

Yanik, T., & Durhan, S. T. (2023). Specific Functions of Melanocortin 3 Receptor (MC3R). Journal of clinical research in pediatric endocrinology, 15(1), 1.

Feng, W., Zhou, Q., Chen, X., Dai, A., Cai, X., Liu, X., ... & Wang, M. W. (2023). Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discovery, 9(1), 81.

Ji, R. L., Huang, L., Wang, Y., Liu, T., Fan, S. Y., Tao, M., & Tao, Y. X. (2021). Topmouth culter melanocortin-3 receptor: Regulation by two isoforms of melanocortin-2 receptor accessory protein 2. Endocrine Connections, 10(11), 1489-1501.

Sweeney, P., Bedenbaugh, M. N., Maldonado, J., Pan, P., Fowler, K., Williams, S. Y., ... & Cone, R. D. (2021). The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia. Science translational medicine, 13(590), eabd6434.

Díaz-Urbina, D., Escartín-Pérez, R. E., Escobar, C., Mancilla-Díaz, J. M., & López-Alonso, V. E. (2021). Stimulation of melanocortin-3 receptors accelerates the satiation process and increases the α-MSH expression in high-fat diet-fed rats. Behavioral Neuroscience, 135(4), 528.

Zhang, H. J., Cui, Z. H., Liu, M., Min, T. Q., Xiao, X., Wang, Z. Q., & Tao, Y. X. (2021). Pharmacological characterization of three chicken melanocortin-3 receptor mutants. Domestic Animal Endocrinology, 74, 106507.

Ehtesham, S., Qasim, A., & Meyre, D. (2019). Loss‐of‐function mutations in the melanocortin‐3 receptor gene confer risk for human obesity: A systematic review and meta‐analysis. Obesity Reviews, 20(8), 1085-1092.

Zhang, H. J., Xie, H. J., Wang, W., Wang, Z. Q., & Tao, Y. X. (2019). Pharmacology of the giant panda (Ailuropoda melanoleuca) melanocortin-3 receptor. General and Comparative Endocrinology, 277, 73-81.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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