Human MC3R ELISA Kit (V2LY-0626-LY4251)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0049 ng/mL
Detection Range
0.01-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
36.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
MELANOCORTIN 3 RECEPTOR
Function
Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Circadian regulation of gene expression Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Homoiothermy Source: Ensembl
Locomotor rhythm Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of blood pressure Source: Ensembl
Regulation of feeding behavior Source: Ensembl
Regulation of heart rate Source: Ensembl
Regulation of metabolic process Source: GO_Central
Sodium ion homeostasis Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-37
Helical: 38-63
Cytoplasmic: 64-75
Helical: 76-100
Extracellular: 101-118
Helical: 119-140
Cytoplasmic: 141-160
Helical: 161-181
Extracellular: 182-186
Helical: 187-210
Cytoplasmic: 211-245
Helical: 246-268
Extracellular: 269-277
Helical: 278-301
Cytoplasmic: 302-323

Yanik, T., & Durhan, S. T. (2023). Specific Functions of Melanocortin 3 Receptor (MC3R). Journal of clinical research in pediatric endocrinology, 15(1), 1.

Feng, W., Zhou, Q., Chen, X., Dai, A., Cai, X., Liu, X., ... & Wang, M. W. (2023). Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discovery, 9(1), 81.

Ji, R. L., Huang, L., Wang, Y., Liu, T., Fan, S. Y., Tao, M., & Tao, Y. X. (2021). Topmouth culter melanocortin-3 receptor: Regulation by two isoforms of melanocortin-2 receptor accessory protein 2. Endocrine Connections, 10(11), 1489-1501.

Sweeney, P., Bedenbaugh, M. N., Maldonado, J., Pan, P., Fowler, K., Williams, S. Y., ... & Cone, R. D. (2021). The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia. Science translational medicine, 13(590), eabd6434.

Díaz-Urbina, D., Escartín-Pérez, R. E., Escobar, C., Mancilla-Díaz, J. M., & López-Alonso, V. E. (2021). Stimulation of melanocortin-3 receptors accelerates the satiation process and increases the α-MSH expression in high-fat diet-fed rats. Behavioral Neuroscience, 135(4), 528.

Zhang, H. J., Cui, Z. H., Liu, M., Min, T. Q., Xiao, X., Wang, Z. Q., & Tao, Y. X. (2021). Pharmacological characterization of three chicken melanocortin-3 receptor mutants. Domestic Animal Endocrinology, 74, 106507.

Ehtesham, S., Qasim, A., & Meyre, D. (2019). Loss‐of‐function mutations in the melanocortin‐3 receptor gene confer risk for human obesity: A systematic review and meta‐analysis. Obesity Reviews, 20(8), 1085-1092.

Zhang, H. J., Xie, H. J., Wang, W., Wang, Z. Q., & Tao, Y. X. (2019). Pharmacology of the giant panda (Ailuropoda melanoleuca) melanocortin-3 receptor. General and Comparative Endocrinology, 277, 73-81.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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