MC3R

This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.

Full Name

MELANOCORTIN 3 RECEPTOR

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Circadian regulation of gene expression Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Homoiothermy Source: Ensembl
Locomotor rhythm Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of blood pressure Source: Ensembl
Regulation of feeding behavior Source: Ensembl
Regulation of heart rate Source: Ensembl
Regulation of metabolic process Source: GO_Central
Sodium ion homeostasis Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-37
Helical: 38-63
Cytoplasmic: 64-75
Helical: 76-100
Extracellular: 101-118
Helical: 119-140
Cytoplasmic: 141-160
Helical: 161-181
Extracellular: 182-186
Helical: 187-210
Cytoplasmic: 211-245
Helical: 246-268
Extracellular: 269-277
Helical: 278-301
Cytoplasmic: 302-323