Mouse Anti-MC5R Recombinant Antibody (CBFYM-0213) (CBMAB-M0256-FY)

This product is mouse antibody that recognizes MC5R. The antibody CBFYM-0213 can be used for immunoassay techniques such as: FC.
See all MC5R antibodies

Published Data

Fig.1 PC3 cells were harvested as described above, and immunoprecipitates were separated by 10% SDS-PAGE and then immunoblotted for CB2 or melanocortin-5 (MC5).

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-0213

Antibody Isotype

IgG2a

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MELANOCORTIN 5 RECEPTOR

Introduction

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.

Entrez Gene ID

4161

UniProt ID

P33032

Alternative Names

Melanocortin 5 Receptor; Melanocortin Receptor 5; MC5-R; MC-2; MC2

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Regulation of metabolic process Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-37
Helical: 38-61
Cytoplasmic: 62-73
Helical: 74-97
Extracellular: 98-114
Helical: 115-138
Cytoplasmic: 139-155
Helical: 156-179
Extracellular: 180-186
Helical: 187-211
Cytoplasmic: 212-239
Helical: 240-265
Extracellular: 266-273
Helical: 274-297
Cytoplasmic: 298-325

References

Feng, W., Zhou, Q., Chen, X., Dai, A., Cai, X., Liu, X., ... & Wang, M. W. (2023). Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discovery, 9(1), 81.

Ji, L. Q., Hong, Y., & Tao, Y. X. (2022). Melanocortin-5 receptor: Pharmacology and its regulation of energy metabolism. International Journal of Molecular Sciences, 23(15), 8727.

Xu, Y., Guan, X., Zhou, R., & Gong, R. (2020). Melanocortin 5 receptor signaling pathway in health and disease. Cellular and Molecular Life Sciences, 77, 3831-3840.

Dores, R. M., Oberer, N., Hoglin, B., Thomas, A., Faught, E., & Vijayan, M. M. (2020). Evaluating interactions between the melanocortin-5 receptor, MRAP1, and ACTH (1–24): A phylogenetic study. General and Comparative Endocrinology, 294, 113476.

Zhu, M., Wang, M., Chen, Y., & Zhang, C. (2019). Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. Journal of Molecular Endocrinology, 62(1), 27-36.

Liao, S., Dong, J., Xu, W., Xi, B., Tao, Y., Liu, B., & Xie, J. (2019). Molecular cloning, tissue distribution, and pharmacological characterization of blunt snout bream (Megalobrama amblycephala) melanocortin-5 receptor. Fish physiology and biochemistry, 45, 311-321.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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