MC5R

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.

Full Name

MELANOCORTIN 5 RECEPTOR

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Regulation of metabolic process Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-37
Helical: 38-61
Cytoplasmic: 62-73
Helical: 74-97
Extracellular: 98-114
Helical: 115-138
Cytoplasmic: 139-155
Helical: 156-179
Extracellular: 180-186
Helical: 187-211
Cytoplasmic: 212-239
Helical: 240-265
Extracellular: 266-273
Helical: 274-297
Cytoplasmic: 298-325