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Mouse Anti-MCHR1 (AA 2-113) Recombinant Antibody (CBFYM-1871) (CBMAB-M2042-FY)

This product is mouse antibody that recognizes MCHR1. The antibody CBFYM-1871 can be used for immunoassay techniques such as: WB,.
See all MCHR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYM-1871
Antibody Isotype
IgG2a
Application
WB,

Basic Information

Immunogen
Recombinant human MCHR1, Ser2-Pro113
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-113

Target

Full Name
MELANIN CONCENTRATING HORMONE RECEPTOR 1
Introduction
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
Entrez Gene ID
Human2847
Mouse207911
Rat83567
UniProt ID
HumanQ99705
MouseQ8JZL2
RatP97639
Alternative Names
Melanin Concentrating Hormone Receptor 1; Melanin-Concentrating Hormone Receptor 1; Somatostatin Receptor-Like Protein; G Protein-Coupled Receptor 24; MCH Receptor 1; MCH-1R; GPR24; MCH1R
Function
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ProtInc
Cell surface receptor signaling pathway Source: Ensembl
Feeding behavior Source: ProtInc
Generation of precursor metabolites and energy Source: ProtInc
G protein-coupled receptor signaling pathway Source: ProtInc
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of calcium ion transport Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-113
Helical: 114-136
Cytoplasmic: 137-148
Helical: 149-171
Extracellular: 172-185
Helical: 186-208
Cytoplasmic: 209-227
Helical: 228-250
Extracellular: 251-278
Helical: 279-301
Cytoplasmic: 302-321
Helical: 322-344
Extracellular: 345-358
Helical: 359-381
Cytoplasmic: 382-422

Sariyer, E., & Sariyer, A. S. (2023). Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB-127158 and KRX-104130. Journal of Bioenergetics and Biomembranes, 1-12.

Huszár, J., Bozó, É., Beke, G., Katalin Szalai, K., Kardos, P., Boros, A., ... & Éles, J. (2022). hERG Optimization of Benzofuro− Pyridine and Pyrazino− Indole Derivatives as MCHR1 Antagonists. ChemMedChem, 17(7), e202100707.

Lim, G., You, K. Y., Lee, J. H., Jeon, M. K., Lee, B. H., Ryu, J. Y., & Oh, K. S. (2022). Identification and new indication of melanin-concentrating hormone receptor 1 (MCHR1) antagonist derived from machine learning and transcriptome-based drug repositioning approaches. International Journal of Molecular Sciences, 23(7), 3807.

Wang, M., Zhai, Y., Lei, X., Xu, J., Jiang, B., Kuang, Z., ... & Zhang, C. (2022). Determination of the Interaction and Pharmacological Modulation of MCHR1 Signaling by the C-Terminus of MRAP2 Protein. Frontiers in Endocrinology, 13, 848728.

Takamura, N., Renaud, L., da Silveira, W. A., & Feghali-Bostwick, C. (2021). PDGF promotes dermal fibroblast activation via a novel mechanism mediated by signaling through MCHR1. Frontiers in Immunology, 12, 745308.

Hsiao, Y. C., Muñoz-Estrada, J., Tuz, K., & Ferland, R. J. (2021). The transition zone protein AHI1 regulates neuronal ciliary trafficking of MCHR1 and its downstream signaling pathway. Journal of Neuroscience, 41(17), 3932-3943.

Diniz, G. B., Battagello, D. S., Klein, M. O., Bono, B. S., Ferreira, J. G., Motta‐Teixeira, L. C., ... & Bittencourt, J. C. (2020). Ciliary melanin‐concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex‐independent manner. Journal of neuroscience research, 98(10), 2045-2071.

Pałasz, A., Piwowarczyk-Nowak, A., Suszka-Świtek, A., Bogus, K., Filipczyk, Ł., Vecchia, A. D., ... & Wiaderkiewicz, R. (2020). Escitalopram as a modulator of proopiomelanocortin, kisspeptin, Kiss1R and MCHR1 gene expressions in the male rat brain. Molecular Biology Reports, 47, 8273-8278.

Balber, T., Benčurová, K., Kiefer, F. W., Kulterer, O. C., Klebermass, E. M., Egger, G., ... & Philippe, C. (2019). In vitro radiopharmaceutical evidence for MCHR1 binding sites in murine brown adipocytes. Frontiers in Endocrinology, 10, 324.

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For research use only. Not intended for any clinical use.

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