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MCHR1

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.

Full Name

MELANIN CONCENTRATING HORMONE RECEPTOR 1

Function

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ProtInc
Cell surface receptor signaling pathway Source: Ensembl
Feeding behavior Source: ProtInc
Generation of precursor metabolites and energy Source: ProtInc
G protein-coupled receptor signaling pathway Source: ProtInc
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of calcium ion transport Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-113
Helical: 114-136
Cytoplasmic: 137-148
Helical: 149-171
Extracellular: 172-185
Helical: 186-208
Cytoplasmic: 209-227
Helical: 228-250
Extracellular: 251-278
Helical: 279-301
Cytoplasmic: 302-321
Helical: 322-344
Extracellular: 345-358
Helical: 359-381
Cytoplasmic: 382-422

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Anti-MCHR1 antibodies

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Mouse Anti-MCHR1 Recombinant Antibody (3D7) (CBMAB-A3544-LY)

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Target: MCHR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3D7

Application*: WB, E

Mouse Anti-MCHR1 Recombinant Antibody (3D7)

Mouse Anti-MCHR1 (AA 2-113) Recombinant Antibody (CBFYM-1871) (CBMAB-M2042-FY)

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Target: MCHR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBFYM-1871

Application*: WB

Mouse Anti-MCHR1 (AA 2-113) Recombinant Antibody (CBFYM-1871)

Mouse Anti-MCHR1 (AA 14-114) Recombinant Antibody (CBFYM-0506) (CBMAB-M0634-FY)

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Target: MCHR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-0506

Application*: E, WB

Mouse Anti-MCHR1 (AA 14-114) Recombinant Antibody (CBFYM-0506)

Human MCHR1 ELISA Kit (V2LY-0626-LY4226)

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Target: MCHR1

Sensitivity: 0.23 ng/mL

Detection Range: 0.5-60 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human MCHR1 ELISA Kit

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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