MCHR1

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.

Full Name

MELANIN CONCENTRATING HORMONE RECEPTOR 1

Function

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ProtInc
Cell surface receptor signaling pathway Source: Ensembl
Feeding behavior Source: ProtInc
Generation of precursor metabolites and energy Source: ProtInc
G protein-coupled receptor signaling pathway Source: ProtInc
Neuropeptide signaling pathway Source: GO_Central
Positive regulation of calcium ion transport Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-113
Helical: 114-136
Cytoplasmic: 137-148
Helical: 149-171
Extracellular: 172-185
Helical: 186-208
Cytoplasmic: 209-227
Helical: 228-250
Extracellular: 251-278
Helical: 279-301
Cytoplasmic: 302-321
Helical: 322-344
Extracellular: 345-358
Helical: 359-381
Cytoplasmic: 382-422