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Mouse Anti-ME1 (AA 1-573) Recombinant Antibody (CBFYM-1973) (CBMAB-M2148-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1973
Antibody Isotype
IgG1, k
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-573

Target

Full Name
malic enzyme 1, NADP(+)-dependent, cytosolic
Introduction
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
Entrez Gene ID
4199
UniProt ID
P48163
Alternative Names
Malic Enzyme 1; Malate Dehydrogenase (Oxaloacetate-Decarboxylating) (NADP(+)); Malic Enzyme 1, NADP(+)-Dependent, Cytosolic; NADP-Dependent Malic Enzyme; EC 1.1.1.40; NADP-ME; Malic Enzyme, Cytoplasmic
Function
Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and decarboxylation of oxaloacetate.
Biological Process
Carbohydrate metabolic process Source: ProtInc
Malate metabolic process Source: UniProtKB
Nucleotide biosynthetic process Source: UniProtKB
Pyruvate metabolic process Source: GO_Central
Regulation of NADP metabolic process Source: CACAO
Response to carbohydrate Source: UniProtKB
Response to hormone Source: UniProtKB
Cellular Location
Cytoplasm
More Infomation

Simmen, F. A., Pabona, J. M. P., Al-Dwairi, A., Alhallak, I., Montales, M. T. E., & Simmen, R. C. (2023). Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice. International Journal of Molecular Sciences, 24(7), 6613.

Fang, X., Zhang, J., Li, Y., Song, Y., Yu, Y., Cai, Z., ... & Wang, F. (2023). Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury. Advanced Science, 10(13), 2205436.

Yoshida, T., Kawabe, T., Cantley, L. C., & Lyssiotis, C. A. (2022). Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP+-Dependent Malic Enzyme 1. Biochemistry, 61(15), 1548-1553.

Badia, M. B., Maurino, V. G., Pavlovic, T., Arias, C. L., Pagani, M. A., Andreo, C. S., ... & Gerrard Wheeler, M. C. (2020). Loss of function of Arabidopsis NADP‐malic enzyme 1 results in enhanced tolerance to aluminum stress. The Plant Journal, 101(3), 653-665.

Nakashima, C., Kirita, T., Yamamoto, K., Mori, S., Luo, Y., Sasaki, T., ... & Kuniyasu, H. (2020). Malic enzyme 1 is associated with tumor budding in oral squamous cell carcinomas. International Journal of Molecular Sciences, 21(19), 7149.

Simmen, F. A., Alhallak, I., & Simmen, R. C. (2020). Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism. Journal of molecular endocrinology, 65(4), R77-R90.

Liu, C., Cao, J., Lin, S., Zhao, Y., Zhu, M., Tao, Z., & Hu, X. (2020). Malic enzyme 1 indicates worse prognosis in breast cancer and promotes metastasis by manipulating reactive oxygen species. OncoTargets and therapy, 8735-8747.

Shi, Y., Zhou, S., Wang, P., Guo, Y., Xie, B., & Ding, S. (2019). Malic enzyme 1 (ME1) is a potential oncogene in gastric cancer cells and is associated with poor survival of gastric cancer patients. OncoTargets and therapy, 12, 5589.

Yazdanpanah, F., Maurino, V. G., Mettler-Altmann, T., Buijs, G., Bailly, M., Karimi Jashni, M., ... & Bentsink, L. (2019). NADP-MALIC ENZYME 1 affects germination after seed storage in Arabidopsis thaliana. Plant and Cell Physiology, 60(2), 318-328.

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For research use only. Not intended for any clinical use.

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