ME1

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq]

malic enzyme 1, NADP(+)-dependent, cytosolic

Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and decarboxylation of oxaloacetate.

Carbohydrate metabolic process Source: ProtInc
Malate metabolic process Source: UniProtKB
Nucleotide biosynthetic process Source: UniProtKB
Pyruvate metabolic process Source: GO_Central
Regulation of NADP metabolic process Source: CACAO
Response to carbohydrate Source: UniProtKB
Response to hormone Source: UniProtKB

Cytoplasm