Mouse Anti-MED26 Recombinant Antibody (2216C1a) (CBMAB-1603-CN)

Name: Mouse Anti-MED26 Recombinant Antibody (2216C1a)
SKU: CBMAB-1603-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2216C1a

Application

ChIP, Dot, WB

Immunogen

Recombinant fragment carrying aa. 50-200 of human CRSP7.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mediator Complex Subunit 26

Introduction

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

Entrez Gene ID

9441

UniProt ID

O95402

Alternative Names

CRSP7; CRSP70

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

Biological Process

Positive regulation of gene expression Source: GO_Central
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: UniProtKB
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Transcription initiation from RNA polymerase II promoter Source: ProtInc

Cellular Location

Nucleus

Suzuki, H., Furugori, K., Abe, R., Ogawa, S., Ito, S., Akiyama, T., ... & Takahashi, H. (2023). MED26‐containing Mediator may orchestrate multiple transcription processes through organization of nuclear bodies. BioEssays, 45(4), 2200178.

Xu, M., & Martinez, E. (2021). A simple protocol to purify human TFIID free of the MED26 subunit of mediator complex. Protein Expression and Purification, 184, 105887.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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