MED26

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
Full Name
Mediator Complex Subunit 26
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Biological Process
Positive regulation of gene expression Source: GO_Central
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: UniProtKB
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Transcription initiation from RNA polymerase II promoter Source: ProtInc
Cellular Location
Nucleus
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Anti-MED26 antibodies

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Mouse Anti-MED26 Recombinant Antibody (2216C1a) (CBMAB-1603-CN)

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Target: MED26
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2216C1a
Application*: CI, DB, WB
Datasheet SDS

Rabbit Anti-MED26 Recombinant Antibody (D4B1X) (CBMAB-CP1487-LY)

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Target: MED26
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4B1X
Application*: WB, IP, CI
Datasheet SDS

Mouse Anti-MED26 Recombinant Antibody (2G10) (CBMAB-A1867-LY)

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Target: MED26
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G10
Application*: WB, E
Datasheet SDS

Mouse Anti-MED26 Recombinant Antibody (CBLC235-LY) (CBMAB-C12047-LY)

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Target: MED26
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLC235-LY
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-MED26 (AA 7-70) Recombinant Antibody (CBFYC-2945) (CBMAB-C3021-FY)

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Target: MED26
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2945
Application*: DB, WB
Datasheet SDS

Mouse Anti-MED26 Recombinant Antibody (CBFYM-2007) (CBMAB-M2185-FY)

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Target: MED26
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2007
Application*: WB
Datasheet SDS

Mouse Anti-MED26 (AA 501-601) Recombinant Antibody (CBFYM-2006) (CBMAB-M2184-FY)

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Target: MED26
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2006
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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