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Mouse Anti-MED26 Recombinant Antibody (CBFYM-2007) (CBMAB-M2185-FY)

This product is mouse antibody that recognizes MED26. The antibody CBFYM-2007 can be used for immunoassay techniques such as: WB.
See all MED26 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2007
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant human Cofactor Required for Sp1 Transcriptional Activation Subunit 7, 70kD
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mediator Complex Subunit 26
Introduction
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
Entrez Gene ID
9441
UniProt ID
O95402
Alternative Names
Mediator Complex Subunit 26; Cofactor Required For Sp1 Transcriptional Activation, Subunit 7, 70kDa; Cofactor Required For Sp1 Transcriptional Activation Subunit 7; Activator-Recruited Cofactor 70 KDa Component; Transcriptional Coactivator CRSP70; CRSP Complex Subunit 7
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
Biological Process
Positive regulation of gene expression Source: GO_Central
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: UniProtKB
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Transcription initiation from RNA polymerase II promoter Source: ProtInc
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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