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Mouse Anti-MEMO1 (AA 1-297) Recombinant Antibody (CBFYM-0014) (CBMAB-M0018-FY)

This product is mouse antibody that recognizes MEMO1. The antibody CBFYM-0014 can be used for immunoassay techniques such as: WB, ELISA.
See all MEMO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0014
Antibody Isotype
IgG1, k
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human MEMO1 (1-297aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-297

Target

Full Name
Mediator Of Cell Motility 1
Introduction
MEMO1 is a Protein Coding gene. Among its related pathways are Signaling by ERBB2 and Signaling by GPCR.
Entrez Gene ID
51072
UniProt ID
Q9Y316
Alternative Names
Mediator Of Cell Motility 1; Hepatitis C Virus NS5A-Transactivated Protein 7; Mediator Of ErbB2-Driven Cell Motility 1; HCV NS5A-Transactivated Protein 7; C21orf19-Like Protein; NS5ATP7; C2orf4
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Biological Process
Regulation of microtubule-based process Source: UniProtKB
Cellular Location
Cytosol
Nucleus

Ramshekar, A., Wallace-Carrete, C., Zaugg, C. J., Nguyen, J., & Hartnett, M. E. (2023). Elucidating the role of MEMO1 in VEGFR2-triggered signaling in retinal microvascular endothelial cells. Investigative Ophthalmology & Visual Science, 64(8), 1244-1244.

Zhang, X., Walke, G. R., Horvath, I., Kumar, R., Blockhuys, S., Holgersson, S., ... & Wittung-Stafshede, P. (2022). Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. Proceedings of the National Academy of Sciences, 119(37), e2206905119.

Ren, X., Jing, Y. X., Zhou, Z. W., & Yang, J. W. (2022). Knockdown of circRNA-Memo1 reduces hypoxia/reoxygenation injury in human brain endothelial cells through miRNA-17-5p/SOS1 axis. Molecular Neurobiology, 59(4), 2085-2097.

Shan, K. S., Li, W. W., Ren, W., Kong, S., Peng, L. P., Zhuo, H. Q., & Tian, S. B. (2022). LncRNA cancer susceptibility 20 regulates the metastasis of human gastric cancer cells via the miR-143-5p/MEMO1 molecular axis. World Journal of Gastroenterology, 28(16), 1656.

Trejo-Cerro, O., Massimi, P., Broniarczyk, J., Myers, M., & Banks, L. (2022). Repression of Memo1, a Novel Target of Human Papillomavirus Type 16 E7, Increases Cell Proliferation in Cervical Cancer Cells. Journal of Virology, 96(20), e01229-22.

Schotanus, M. D., & Van Otterloo, E. (2020). Finding MEMO—Emerging Evidence for MEMO1′ s Function in Development and Disease. Genes, 11(11), 1316.

Ding, C., Xi, G., Wang, G., Cui, D., Zhang, B., Wang, H., ... & Wang, J. (2020). Exosomal Circ-MEMO1 promotes the progression and aerobic glycolysis of non-small cell lung cancer through targeting MiR-101-3p/KRAS axis. Frontiers in Genetics, 11, 962.

Xu, K., Shi, J., Mo, D., Yang, Y., Fu, Q., & Luo, Y. (2020). miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1. Cancer biology & therapy, 21(12), 1163-1170.

Moor, M. B., Ramakrishnan, S. K., Legrand, F., Bachtler, M., Koesters, R., Hynes, N. E., ... & Bonny, O. (2020). Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice. PLoS One, 15(7), e0236361.

Nakagawa, N., Plestant, C., Yabuno-Nakagawa, K., Li, J., Lee, J., Huang, C. W., ... & Anton, E. S. (2019). Memo1-mediated tiling of radial glial cells facilitates cerebral cortical development. Neuron, 103(5), 836-852.

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For research use only. Not intended for any clinical use.

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