Human MEMO1 ELISA Kit (V2LY-0626-LY5105)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0042 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
33.7 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Mediator Of Cell Motility 1
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Biological Process
Regulation of microtubule-based process Source: UniProtKB
Cellular Location
Cytosol
Nucleus

Ramshekar, A., Wallace-Carrete, C., Zaugg, C. J., Nguyen, J., & Hartnett, M. E. (2023). Elucidating the role of MEMO1 in VEGFR2-triggered signaling in retinal microvascular endothelial cells. Investigative Ophthalmology & Visual Science, 64(8), 1244-1244.

Zhang, X., Walke, G. R., Horvath, I., Kumar, R., Blockhuys, S., Holgersson, S., ... & Wittung-Stafshede, P. (2022). Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. Proceedings of the National Academy of Sciences, 119(37), e2206905119.

Ren, X., Jing, Y. X., Zhou, Z. W., & Yang, J. W. (2022). Knockdown of circRNA-Memo1 reduces hypoxia/reoxygenation injury in human brain endothelial cells through miRNA-17-5p/SOS1 axis. Molecular Neurobiology, 59(4), 2085-2097.

Shan, K. S., Li, W. W., Ren, W., Kong, S., Peng, L. P., Zhuo, H. Q., & Tian, S. B. (2022). LncRNA cancer susceptibility 20 regulates the metastasis of human gastric cancer cells via the miR-143-5p/MEMO1 molecular axis. World Journal of Gastroenterology, 28(16), 1656.

Trejo-Cerro, O., Massimi, P., Broniarczyk, J., Myers, M., & Banks, L. (2022). Repression of Memo1, a Novel Target of Human Papillomavirus Type 16 E7, Increases Cell Proliferation in Cervical Cancer Cells. Journal of Virology, 96(20), e01229-22.

Schotanus, M. D., & Van Otterloo, E. (2020). Finding MEMO—Emerging Evidence for MEMO1′ s Function in Development and Disease. Genes, 11(11), 1316.

Ding, C., Xi, G., Wang, G., Cui, D., Zhang, B., Wang, H., ... & Wang, J. (2020). Exosomal Circ-MEMO1 promotes the progression and aerobic glycolysis of non-small cell lung cancer through targeting MiR-101-3p/KRAS axis. Frontiers in Genetics, 11, 962.

Xu, K., Shi, J., Mo, D., Yang, Y., Fu, Q., & Luo, Y. (2020). miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1. Cancer biology & therapy, 21(12), 1163-1170.

Moor, M. B., Ramakrishnan, S. K., Legrand, F., Bachtler, M., Koesters, R., Hynes, N. E., ... & Bonny, O. (2020). Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice. PLoS One, 15(7), e0236361.

Nakagawa, N., Plestant, C., Yabuno-Nakagawa, K., Li, J., Lee, J., Huang, C. W., ... & Anton, E. S. (2019). Memo1-mediated tiling of radial glial cells facilitates cerebral cortical development. Neuron, 103(5), 836-852.

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For research use only. Not intended for any clinical use.

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