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Mouse Anti-MESP2 Antibody (1D4) (CBMAB-0671-YC)

Provided herein are mouse monoclonal antibodies against Human MESP2. The antibody clone 1D4 can be used for immunoassay techniques, such as IP, WB and MA.
See all MESP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D4
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MESP2
Introduction
MESP2 (mesoderm posterior 2 homolog) is a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. MESP2 also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
Entrez Gene ID
145873
UniProt ID
Q0VG99
Alternative Names
bHLHc6; SCDO2
Function
Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
Biological Process
Heart morphogenesis Source: GO_Central
Mesoderm formation Source: GO_Central
Notch signaling pathway Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Somite rostral/caudal axis specification Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Spondylocostal dysostosis 2, autosomal recessive (SCDO2):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
PTM
Degraded by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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