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Mouse Anti-MESP2 (AA 37-94) Recombinant Antibody (CBFYM-2090) (CBMAB-M2271-FY)

This product is mouse antibody that recognizes MESP2. The antibody CBFYM-2090 can be used for immunoassay techniques such as: ELISA, WB.
See all MESP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2090
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant fragment of human MESP2 (AA: 37-94) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 37-94

Target

Full Name
MESP2
Introduction
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2.
Entrez Gene ID
145873
UniProt ID
Q0VG99
Alternative Names
Mesoderm Posterior BHLH Transcription Factor 2; Mesoderm Posterior Basic Helix-Loop-Helix Transcription Factor 2; Class C Basic Helix-Loop-Helix Protein 6; BHLHc6; SCDO2; Mesoderm Posterior 2 Homolog (Mouse); Mesoderm Posterior 2 Homolog; Mesoderm Posterior Protein 2
Function
Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
Biological Process
Heart morphogenesis Source: GO_Central
Mesoderm formation Source: GO_Central
Notch signaling pathway Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Somite rostral/caudal axis specification Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Spondylocostal dysostosis 2, autosomal recessive (SCDO2):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
PTM
Degraded by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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