Mouse Anti-MESP2 Recombinant Antibody (CBT2431) (V2LY-0625-LY2786)

Name: Mouse Anti-MESP2 Recombinant Antibody (CBT2431)
SKU: V2LY-0625-LY2786
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-MESP2 Recombinant Antibody (CBT2431) (V2LY-0625-LY2786) in WB

Mouse Anti-MESP2 Recombinant Antibody (CBT2431) (V2LY-0625-LY2786) in ELISA

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2431

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Purified recombinant fragment of human MESP2 (AA: 37-94 ) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID

145873

UniProt ID

Q0VG99

Function

Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.

Biological Process

Heart morphogenesis Source: GO_Central
Mesoderm formation Source: GO_Central
Notch signaling pathway Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Somite rostral/caudal axis specification Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Spondylocostal dysostosis 2, autosomal recessive (SCDO2):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.

PTM

Degraded by the proteasome.

More Infomation

References

Cai, S., Chen, M., Xue, B., Zhu, Z., Wang, X., Li, J., ... & Zeng, X. (2023). Retinoic acid enhances ovarian steroidogenesis by regulating granulosa cell proliferation and MESP2/STAR/CYP11A1 pathway. Journal of Advanced Research.

Ge, L., Zhao, G., Lan, C., Song, H., Qi, D., Huang, P., ... & Cui, H. (2023). MESP2 binds competitively to TCF4 to suppress gastric cancer progression by regulating the SKP2/p27 axis. Cell Death Discovery, 9(1), 79.

Okada, H., & Saga, Y. (2022). Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1. PLoS Genetics, 18(1), e1010000.

Ajima, R., Sakakibara, Y., Sakurai-Yamatani, N., Muraoka, M., & Saga, Y. (2021). Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice. Development, 148(20), dev194613.

Zhang, E., Yang, J., Liu, Y., Hong, N., Xie, H., Fu, Q., ... & Sun, K. (2020). MESP2 variants contribute to conotruncal heart defects by inhibiting cardiac neural crest cell proliferation. Journal of Molecular Medicine, 98, 1035-1048.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MESP2 Recombinant Antibody (1E11) (CAT#: CBMAB-A5436-LY)

Mouse Anti-MESP2 Recombinant Antibody (CBFYM-0625) (CAT#: CBMAB-M0759-FY)

Mouse Anti-MESP2 (AA 37-94) Recombinant Antibody (CBFYM-2090) (CAT#: CBMAB-M2271-FY)

Mouse Anti-MESP2 Antibody (1D4) (CAT#: CBMAB-0671-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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