Rat Anti-METRN (AA 22-291) Recombinant Antibody (CBFYM-2118) (CBMAB-M2300-FY)

Name: Rat Anti-METRN (AA 22-291) Recombinant Antibody (CBFYM-2118)
SKU: CBMAB-M2300-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYM-2118

Application

ELISA

Immunogen

Recombinant corresponding to AA 22-291 from Meteorin expressed in NSO cells (Q8C1Q4).Immunogen type: Recombinant protein

Specificity

Mouse

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 22-291

More Infomation

Target

Full Name

METEORIN, GLIAL CELL DIFFERENTIATION REGULATOR

Introduction

Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis.

Entrez Gene ID

79006

UniProt ID

Q9UJH8

Alternative Names

Meteorin, Glial Cell Differentiation Regulator; C16orf23; Chromosome 16 Open Reading Frame 23; C380A1.2; Meteorin

Function

Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).

Biological Process

Glial cell differentiation Source: GO_Central
Positive regulation of axonogenesis Source: GO_Central

Cellular Location

Secreted

Wang, X., Cao, Q., Shi, Y., Wu, X., Mi, Y., Liu, K., ... & Zhang, M. (2021). Identification of low-dose radiation-induced exosomal circ-METRN and miR-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance. International Journal of Biological Sciences, 17(4), 1061.

Xu, X., Zhang, C., Xia, Y., & Yu, J. (2020). Over expression of METRN predicts poor clinical prognosis in colorectal cancer. Molecular Genetics & Genomic Medicine, 8(3), e1102.

Cao, Q., Shi, Y., Wang, X., Yang, J., Mi, Y., Zhai, G., & Zhang, M. (2019). Circular METRN RNA hsa_circ_0037251 promotes glioma progression by sponging miR-1229-3p and regulating mTOR expression. Scientific Reports, 9(1), 19791.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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