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Mouse Anti-MIXL1 Recombinant Antibody (4D11) (CBMAB-A5490-LY)

The product is antibody recognizes MIXL1. The antibody 4D11 immunoassay techniques such as: WB, ELISA.
See all MIXL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4D11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MIXL1 (NP_114150, 86 a.a. ~ 185 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mix1 homeobox-like 1 (Xenopus laevis)
Introduction
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM
Entrez Gene ID
83881
UniProt ID
Q9H2W2
Alternative Names
MGC138179; MILD1; MIX; MIXL
Function
Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).
Biological Process
Cell migration involved in gastrulation Source: Ensembl
Digestive tract development Source: BHF-UCL
Endodermal cell differentiation Source: BHF-UCL
Endoderm development Source: BHF-UCL
Endoderm formation Source: GO_Central
Gastrulation Source: BHF-UCL
Heart development Source: BHF-UCL
Hematopoietic progenitor cell differentiation Source: BHF-UCL
Negative regulation of hematopoietic progenitor cell differentiation Source: BHF-UCL
Positive regulation of mesoderm development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated at multiple sites.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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