MIXL1

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM

Mix1 homeobox-like 1 (Xenopus laevis)

Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).

Cell migration involved in gastrulation Source: Ensembl
Digestive tract development Source: BHF-UCL
Endodermal cell differentiation Source: BHF-UCL
Endoderm development Source: BHF-UCL
Endoderm formation Source: GO_Central
Gastrulation Source: BHF-UCL
Heart development Source: BHF-UCL
Hematopoietic progenitor cell differentiation Source: BHF-UCL
Negative regulation of hematopoietic progenitor cell differentiation Source: BHF-UCL
Positive regulation of mesoderm development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus

Phosphorylated at multiple sites.