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MIXL1

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM

Full Name

Mix1 homeobox-like 1 (Xenopus laevis)

Function

Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).

Biological Process

Cell migration involved in gastrulation Source: Ensembl
Digestive tract development Source: BHF-UCL
Endodermal cell differentiation Source: BHF-UCL
Endoderm development Source: BHF-UCL
Endoderm formation Source: GO_Central
Gastrulation Source: BHF-UCL
Heart development Source: BHF-UCL
Hematopoietic progenitor cell differentiation Source: BHF-UCL
Negative regulation of hematopoietic progenitor cell differentiation Source: BHF-UCL
Positive regulation of mesoderm development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

PTM

Phosphorylated at multiple sites.

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Anti-MIXL1 antibodies

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Mouse Anti-MIXL1 Recombinant Antibody (4D11) (CBMAB-A5490-LY)

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Target: MIXL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4D11

Application*: WB, E

Mouse Anti-MIXL1 Recombinant Antibody (4D11)

Rat Anti-MIXL1 (AA 147-231) Recombinant Antibody (CBFYM-2249) (CBMAB-M2433-FY)

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Target: MIXL1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYM-2249

Application*: IC

Rat Anti-MIXL1 (AA 147-231) Recombinant Antibody (CBFYM-2249)

Mouse Anti-MIXL1 (AA 86-185) Recombinant Antibody (CBFYM-2248) (CBMAB-M2432-FY)

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Target: MIXL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2248

Application*: E, WB

Mouse Anti-MIXL1 (AA 86-185) Recombinant Antibody (CBFYM-2248)

Mouse Anti-MIXL1 Recombinant Antibody (CBFYM-0649) (CBMAB-M0785-FY)

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Target: MIXL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-0649

Application*: E, WB

Mouse Anti-MIXL1 Recombinant Antibody (CBFYM-0649)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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