Rat Anti-MIXL1 (AA 147-231) Recombinant Antibody (CBFYM-2249) (CBMAB-M2433-FY)

Name: Rat Anti-MIXL1 (AA 147-231) Recombinant Antibody (CBFYM-2249)
SKU: CBMAB-M2433-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYM-2249

Application

ICC

Immunogen

Recombinant mouse MIXL1, Lys147-Phe231

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 147-231

More Infomation

Target

Full Name

Mix1 homeobox-like 1 (Xenopus laevis)

Introduction

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development.

Entrez Gene ID

27217

UniProt ID

Q9WUI0

Alternative Names

Mix Paired-Like Homeobox; MIX1 Homeobox-Like Protein 1; Mix.1 Homeobox-Like Protein; Homeodomain Protein MIX; MIXL; Mix1 Homeobox (Xenopus Laevis)-Like 1; Mix1 Homeobox-Like 1 (Xenopus Laevis)

Function

Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).

Biological Process

Cell migration involved in gastrulation Source: Ensembl
Digestive tract development Source: BHF-UCL
Endodermal cell differentiation Source: BHF-UCL
Endoderm development Source: BHF-UCL
Endoderm formation Source: GO_Central
Gastrulation Source: BHF-UCL
Heart development Source: BHF-UCL
Hematopoietic progenitor cell differentiation Source: BHF-UCL
Negative regulation of hematopoietic progenitor cell differentiation Source: BHF-UCL
Positive regulation of mesoderm development Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

PTM

Phosphorylated at multiple sites.

Salehin, S. M. (2023). Dissection of the Mixl1 gene regulation network in endoderm development (Doctoral dissertation).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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