Mouse Anti-MLANA (AA 48-118) Recombinant Antibody (CBFYM-0113) (CBMAB-M0131-FY)

Name: Mouse Anti-MLANA (AA 48-118) Recombinant Antibody (CBFYM-0113)
SKU: CBMAB-M0131-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0113

Application

WB, ELISA

Immunogen

Recombinant fragment of human MLANA (AA: 48-118) expressed in E. Coli

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 48-118

More Infomation

Target

Full Name

Melan-A

Introduction

MLANA is a Protein Coding gene. Diseases associated with MLANA include Melanoma and Microphthalmia. Among its related pathways are NF-kappaB Signaling.

Entrez Gene ID

2315

UniProt ID

Q16655

Alternative Names

Melan-A; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MART-1; MART1; Melanoma Antigen Recognized By T-Cells 1

Function

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Biological Process

Golgi apparatus
trans-Golgi network membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Melanosome
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Topology

Helical: 27-47
Cytoplasmic: 48-118

PTM

Acylated.

Rodrigues‐Junior, D. M., Tan, S. S., Lim, S. K., de Souza Viana, L., Carvalho, A. L., Vettore, A. L., & Iyer, N. G. (2019). High expression of MLANA in the plasma of patients with head and neck squamous cell carcinoma as a predictor of tumor progression. Head & Neck, 41(5), 1199-1205.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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