MLANA
MLANA (Melan-A) is a Protein Coding gene. Diseases associated with MLANA include Melanoma and Microphthalmia. Among its related pathways are NF-kappaB Signaling.
Full Name
Melan-A
Function
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Biological Process
Golgi apparatus
trans-Golgi network membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Melanosome
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
trans-Golgi network membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Melanosome
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Topology
Helical: 27-47
Cytoplasmic: 48-118
Cytoplasmic: 48-118
PTM
Acylated.
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Anti-MLANA antibodies
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CompareTarget: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse
Clone: A1124
Application*: FC, IF, IHC, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: A1123
Application*: FC, IF, IHC, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Horse
Clone: A1122
Application*: FC, IF, IHC, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse
Clone: A1121
Application*: FC, IF, IHC, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: A1120
Application*: FC, IF, IHC, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Horse
Clone: A1119
Application*: FC, IF, IHC, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Dog, Human, Mouse
Clone: A1118
Application*: FC, IF, IHC, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A1117
Application*: ELISA, IHC
Target: MLANA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM333
Application*: IHC, WB
Target: MLANA
Host: Mouse
Specificity: Human
Clone: IHC408
Application*: P, E, IH
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A103
Application*: IH
Target: MLANA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2279
Application*: C, P
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2278
Application*: C, P, IP, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2277
Application*: F, P, IP, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2276
Application*: WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2275
Application*: IF, P, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2274
Application*: WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2273
Application*: WB, IH, IF
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Horse, Human
Clone: CBFYM-2272
Application*: IH, IP, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human
Clone: CBFYM-2270
Application*: IH, IP, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-0654
Application*: IH, IP, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0653
Application*: IH, IP, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Mouse, Rat
Clone: CBFYM-0432
Application*: C, F, IF, IP, P, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYM-0431
Application*: C, F, IF, IP, P, WB
Target: MLANA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Horse, Human
Clone: CBFYM-0427
Application*: F, IF, P
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog
Clone: CBFYM-0364
Application*: F, IF, WB, C
Target: MLANA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYM-0363
Application*: F, IF, P, WB
Target: MLANA
Host: Mouse
Specificity: Human
Clone: CBFYM-0113
Application*: WB, E
Target: MLANA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4065
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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