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Mouse Anti-MLANA Recombinant Antibody (CBFYM-0432) (CBMAB-M0547-FY)

This product is mouse antibody that recognizes MLANA. The antibody CBFYM-0432 can be used for immunoassay techniques such as: IHC-Fr, FC, IF, IP, IHC-P, WB.
See all MLANA antibodies

Summary

Host Animal
Mouse
Specificity
Dog, Human, Mouse, Rat
Clone
CBFYM-0432
Antibody Isotype
IgG1
Application
IHC-Fr, FC, IF, IP, IHC-P, WB

Basic Information

Specificity
Dog, Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Melan-A
Introduction
MLANA is a Protein Coding gene. Diseases associated with MLANA include Melanoma and Microphthalmia. Among its related pathways are NF-kappaB Signaling.
Entrez Gene ID
Human2315
Mouse77836
Rat293890
Dog403495
UniProt ID
HumanQ16655
MouseQ2TA50
RatD3ZWI9
DogF6PMG8
Alternative Names
Melan-A; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MART-1; MART1; Melanoma Antigen Recognized By T-Cells 1
Function
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Biological Process
Golgi apparatus
trans-Golgi network membrane
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
Melanosome
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Topology
Helical: 27-47
Cytoplasmic: 48-118
PTM
Acylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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