Mouse Anti-MLLT6 (AA 1-462) Recombinant Antibody (CBFYM-2308) (CBMAB-M2493-FY)

Name: Mouse Anti-MLLT6 (AA 1-462) Recombinant Antibody (CBFYM-2308)
SKU: CBMAB-M2493-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2308

Application

IF, S-ELISA, ELISA, WB-Re

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-462

More Infomation

Target

Full Name

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6

Introduction

MLLT6 is a Protein Coding gene. An important paralog of this gene is MLLT10.

Entrez Gene ID

4302

UniProt ID

P55198

Alternative Names

MLLT6, PHD Finger Containing; Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Translocated To, 6; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 6; ALL1-Fused Gene From Chromosome 17 Protein; MLLT6, PHD Finger Domain Containing; Trithorax Homolog

Biological Process

Negative regulation of histone H3-K79 methylation Source: Ensembl
Negative regulation of urine volume Source: Ensembl
Positive regulation of sodium ion transport Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of transcription, DNA-templated Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Renal potassium excretion Source: Ensembl
Renal sodium excretion Source: Ensembl
Renal water absorption Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with KMT2A/MLL1. The result is a rogue activator protein.

Qiu, L., Nunez, C. A., Tang, G., Cuglievan, B., Issa, G. C., Wang, S. A., ... & Thakral, B. (2022). A rare case of acute megakaryoblastic leukemia with t (11; 17)(q23; q21) and KMT2A:: MLLT6 fusion. Annals of Hematology, 101(7), 1579-1581.

Sreevalsan, S., Döring, M., Paszkowski‐Rogacz, M., Brux, M., Blanck, C., Meyer, M., ... & Theis, M. (2020). MLLT 6 maintains PD‐L1 expression and mediates tumor immune resistance. EMBO reports, 21(12), e50155.

Park, C. G., Mun, S. H., Lee, A. J., Jeon, C. H., Suh, H. S., & Kim, S. G. (2019). Acute Monoblastic Leukemia with t (11; 17)(q23; q21): Fusion of the KMT2A (MLL) and MLLT6 (AF17) Genes. Laboratory Medicine Online, 9(4), 258-262.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MLLT6 Recombinant Antibody (CBFYM-2309) (CAT#: CBMAB-M2494-FY)

Mouse Anti-MLLT6 Recombinant Antibody (1B2) (CAT#: CBMAB-A5520-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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