Mouse Anti-MLX Antibody (1G8) (CBMAB-0680-YC)

Name: Mouse Anti-MLX Antibody (1G8)
SKU: CBMAB-0680-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1G8

Application

IP, MA

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MLX

Introduction

MLX (MAX-like protein X) belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. MLX may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4.

Entrez Gene ID

6945

UniProt ID

Q9UH92

Alternative Names

bHLHd13; MAD7; MXD7; TCFL4

Function

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Biological Process

Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Isoform Alpha:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Beta:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Gamma:
Nucleus
Note: Found predominantly in the nucleus (PubMed:10918583).

Guo, W., Wang, X., Lu, B., Yu, J., Xu, M., Huang, R., ... & Zou, C. (2023). Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma. Cell Death & Disease, 14(7), 439.

Carroll, P. A., Freie, B. W., Cheng, P. F., Kasinathan, S., Gu, H., Hedrich, T., ... & Eisenman, R. N. (2021). The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. PLoS Biology, 19(10), e3001085.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Rabbit Anti-MLX Recombinant Antibody (D8G6W) (CAT#: CBMAB-CP1559-LY)

Mouse Anti-MLX Recombinant Antibody (1C3) (CAT#: CBMAB-A5524-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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