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Mouse Anti-MLX (AA 1-244) Recombinant Antibody (CBFYM-2315) (CBMAB-M2500-FY)

This product is mouse antibody that recognizes MLX. The antibody CBFYM-2315 can be used for immunoassay techniques such as: ELISA, IF.
See all MLX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2315
Antibody Isotype
IgG2a, k
Application
ELISA, IF

Basic Information

Immunogen
Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MTEPGASPED PWVKVEYAYS DNSLDPGLFV ESTRKGSVVS RANSIGSTSA SSVPNTDDED SDYHQEAYKE SYKDRRRRAH TQAEQKRRDA IKRGYDDLQT IVPTCQQQDF SIGSQKLSKA IVLQKTIDYI QFLHKEKKKQ E
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-244

Target

Full Name
MLX
Introduction
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Entrez Gene ID
6945
UniProt ID
Q9UH92
Alternative Names
MLX, MAX Dimerization Protein; Class D Basic Helix-Loop-Helix Protein 13; Transcription Factor-Like Protein 4; MAX-Like Protein X; BHLHd13; TCFL4; Transcription Factor-Like 4; MAX-Like BHLHZIP Protein
Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Biological Process
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Isoform Alpha:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Beta:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Gamma:
Nucleus
Note: Found predominantly in the nucleus (PubMed:10918583).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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