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Rabbit Anti-MLX Recombinant Antibody (D8G6W) (CBMAB-CP1559-LY)

The product is antibody recognizes MLX. The antibody D8G6W immunoassay techniques such as: WB,IP,CIP.
See all MLX antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D8G6W
Antibody Isotype
IgG
Application
WB, IP, CIP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val286 of human MLX protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MLX
Introduction
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human6945
Mouse21428
Rat360631
Monkey710570
UniProt ID
HumanQ9UH92
MouseO08609
RatQ2I1Z0
MonkeyF6YL60
Alternative Names
MLX; MAX Dimerization Protein; Class D Basic Helix-Loop-Helix Protein 13; Transcription Factor-Like Protein 4; MAX-Like Protein X; BHLHd13; TCFL4; Transcription Factor-Like 4; MAX-Like BHLHZIP Protein;
Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Biological Process
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Isoform Alpha:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Beta:
Cytoplasm
Note: Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Gamma:
Nucleus
Note: Found predominantly in the nucleus (PubMed:10918583).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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