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Mouse Anti-MMP16 Recombinant Antibody (CBFYM-2373) (CBMAB-M2560-FY)

This product is mouse antibody that recognizes MMP16. The antibody CBFYM-2373 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all MMP16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2373
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Matrix Metalloproteinase 16
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MATRIX METALLOPEPTIDASE 16
Introduction
Proteins of the matrix metalloproteinase family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Entrez Gene ID
4325
UniProt ID
P51512
Alternative Names
Matrix Metallopeptidase 16; Matrix Metallopeptidase 16 (Membrane-Inserted); Membrane-Type Matrix Metalloproteinase 3; Membrane-Type-3 Matrix Metalloproteinase; MT-MMP 3; C8orf57; MT3-MMP; MMP-16; MMP-X2; MT3MMP; MTMMP3
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Biological Process
Chondrocyte proliferation Source: Ensembl
Collagen catabolic process Source: GO_Central
Craniofacial suture morphogenesis Source: Ensembl
Embryonic cranial skeleton morphogenesis Source: Ensembl
Endochondral ossification Source: Ensembl
Extracellular matrix organization Source: GO_Central
Protein processing Source: ParkinsonsUK-UCL
Proteolysis Source: ParkinsonsUK-UCL
Skeletal system development Source: GO_Central
Cellular Location
Isoform Long:
Plasma membrane
Cell membrane
Note: Localized at the cell surface of melanoma cells.
Isoform Short:
Extracellular region or secreted
extracellular matrix
Other locations
Cell surface
Note: Localized at the cell surface of melanoma cells.
Topology
Extracellular: 120-564
Helical: 565-585
Cytoplasmic: 586-607
PTM
The precursor is cleaved by a furin endopeptidase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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