Human MMP16 ELISA Kit (V2LY-0626-LY4866)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.152 ng/mL
Detection Range
0.3-90 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
69.5 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
MATRIX METALLOPEPTIDASE 16
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Biological Process
Chondrocyte proliferation Source: Ensembl
Collagen catabolic process Source: GO_Central
Craniofacial suture morphogenesis Source: Ensembl
Embryonic cranial skeleton morphogenesis Source: Ensembl
Endochondral ossification Source: Ensembl
Extracellular matrix organization Source: GO_Central
Protein processing Source: ParkinsonsUK-UCL
Proteolysis Source: ParkinsonsUK-UCL
Skeletal system development Source: GO_Central
Cellular Location
Isoform Long:
Plasma membrane
Cell membrane
Note: Localized at the cell surface of melanoma cells.
Isoform Short:
Extracellular region or secreted
extracellular matrix
Other locations
Cell surface
Note: Localized at the cell surface of melanoma cells.
Topology
Extracellular: 120-564
Helical: 565-585
Cytoplasmic: 586-607
PTM
The precursor is cleaved by a furin endopeptidase.

Pietrzak, J., Szmajda-Krygier, D., Wosiak, A., Świechowski, R., Michalska, K., Mirowski, M., ... & Balcerczak, E. (2022). Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC). Biomedicine & Pharmacotherapy, 146, 112559.

Wang, H., Qi, C., & Wan, D. (2021). MicroRNA-377-3p targeting MMP-16 inhibits ovarian cancer cell growth, invasion, and interstitial transition. Annals of Translational Medicine, 9(2).

Zhang, Y., Zeng, S., & Wang, T. (2021). Circular RNA hsa_circ_0002360 promotes non-small cell lung cancer progression through upregulating matrix metalloproteinase 16 and sponging multiple micorRNAs. Bioengineered, 12(2), 12767-12777.

Li, W., Song, Z., Jia, N., Zhang, C., Gao, W., & Wang, L. (2021). microRNA-4429-5p suppresses the malignant development of colon cancer by targeting matrix metalloproteinase 16. In Vitro Cellular & Developmental Biology-Animal, 57(7), 715-725.

Lou, L., Tian, M., Chang, J., Li, F., & Zhang, G. (2020). MiRNA-192-5p attenuates airway remodeling and autophagy in asthma by targeting MMP-16 and ATG7. Biomedicine & Pharmacotherapy, 122, 109692.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Mmp16 ELISA Kit (CAT#: V2LY-0626-LY2426)

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Mouse Anti-MMP16 (AA 32-535) Recombinant Antibody (CBFYM-0206) (CAT#: CBMAB-M0248-FY)

Rabbit Anti-MMP16 (AA 121-545) Recombinant Antibody (CBFYM-2375) (CAT#: CBMAB-M2562-FY)

Rat Mmp16 ELISA Kit (CAT#: V2LY-0626-LY2426)

Mouse Anti-MMP16 Recombinant Antibody (CBFYM-0673) (CAT#: CBMAB-M0809-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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