• Home
  • MNAT1
  • Mouse Anti-MNAT1 Recombinant Antibody (CBFYM-2435)

Mouse Anti-MNAT1 Recombinant Antibody (CBFYM-2435) (CBMAB-M2622-FY)

See all MNAT1 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBFYM-2435
Application
WB, IF
Specificity
Mouse, Rat, Human, Dog
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
MNAT1, CDK Activating Kinase Assembly Factor
Introduction
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human4331
Mouse17420
Rat266713
Dog480346
UniProt ID
HumanP51948
MouseP51949
RatQ8CIR5
DogE2QVF4
Alternative Names
MNAT1, CDK Activating Kinase Assembly Factor; MNAT CDK-Activating Kinase Assembly Factor 1; Menage A Trois 1 (CAK Assembly Factor); CDK7/Cyclin-H Assembly Factor; RING Finger Protein MAT1; RING Finger Protein 66; CAP35; RNF66; MAT1; Menage A Trois Homolog 1, Cyclin H Assembly Factor (Xenopus Laevis); Menage A Trois-Like Protein 1 Cyclin H Assembly Factor
Function
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Biological Process
Adult heart development Source: Ensembl
DNA repair Source: GO_Central
G1/S transition of mitotic cell cycle Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of DNA helicase activity Source: UniProtKB
Nucleotide-excision repair Source: InterPro
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Protein-containing complex assembly Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of G1/S transition of mitotic cell cycle Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: UniProtKB
Response to calcium ion Source: Ensembl
Transcription by RNA polymerase II Source: UniProtKB
Ventricular system development Source: Ensembl
Cellular Location
Nucleus

Xu, Z., Liu, Y., Pan, Z., & Qin, L. (2023). Epigenetic upregulation of MNAT1 by SMYD2 is linked to PI3K/AKT activation and tumorigenesis of pancreatic adenocarcinoma. Histology and Histopathology, 18630-18630.

Zhou, S., Lu, J., Li, Y., Chen, C., Cai, Y., Tan, G., ... & Tang, F. (2021). Retraction Note: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance. Journal of Experimental & Clinical Cancer Research: CR, 40.

Zou, C., Mifflin, L., Hu, Z., Zhang, T., Shan, B., Wang, H., ... & Yuan, J. (2020). Reduction of mNAT1/hNAT2 contributes to cerebral endothelial necroptosis and Aβ accumulation in Alzheimer’s disease. Cell reports, 33(10).

Qiu, C., Su, W., Shen, N., Qi, X., Wu, X., Wang, K., ... & Xiang, H. (2020). MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway. BMC cancer, 20(1), 1-12.

Wang, J., Ni, J., Song, D., Ding, M., Huang, J., Li, W., & He, G. (2020). The regulatory effect of has-circ-0001146/miR-26a-5p/MNAT1 network on the proliferation and invasion of osteosarcoma. Bioscience Reports, 40(6), BSR20201232.

Chen, Y., Guan, J. X., & Shen, H. (2019). MNAT1 expression in non-small cell lung cancer and its biological cellular impact. Zhonghua Bing li xue za zhi= Chinese Journal of Pathology, 48(8), 626-632.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MNAT1 Recombinant Antibody (CBFYM-2435)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Recombinant Mouse Anti-MNAT1 Recombinant Antibody (1G6) (CAT#: CBMAB-XB0829-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry