MNAT1

MNAT1, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II.

Full Name

MNAT1, CDK Activating Kinase Assembly Factor

Function

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Biological Process

Adult heart development Source: Ensembl
DNA repair Source: GO_Central
G1/S transition of mitotic cell cycle Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of DNA helicase activity Source: UniProtKB
Nucleotide-excision repair Source: InterPro
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Protein-containing complex assembly Source: ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of G1/S transition of mitotic cell cycle Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: UniProtKB
Response to calcium ion Source: Ensembl
Transcription by RNA polymerase II Source: UniProtKB
Ventricular system development Source: Ensembl

Cellular Location

Nucleus