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Mouse Anti-MNDA Recombinant Antibody (1H2) (CBMAB-A5538-LY)

The product is antibody recognizes MNDA. The antibody 1H2 immunoassay techniques such as: IHC, ELISA.
See all MNDA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H2
Antibody Isotype
IgG2a, κ
Application
IHC, ELISA

Basic Information

Immunogen
MNDA (NP_002423.1, 311 a.a. ~ 407 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Myeloid Cell Nuclear Differentiation Antigen
Introduction
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq]
Entrez Gene ID
4332
UniProt ID
P41218
Alternative Names
PYHIN3
Function
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Biological Process
Activation of innate immune response Source: GO_Central
B cell receptor signaling pathway Source: UniProtKB
Cellular defense response Source: ProtInc
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to interferon-beta Source: GO_Central
Negative regulation of B cell proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

Gupta, N., Roychoudry, S., Sticco, K. L., Hsu, P., Zhang, X., & Sheikh-Fayyaz, S. (2023). Study of the Utility of Myeloid Cell Nuclear Differentiation Antigen (MNDA) in the Diagnosis of Marginal Zone Lymphoma. Applied Immunohistochemistry & Molecular Morphology, 31(4), 217.

Meng, Y., Zhang, M., Li, X., Dong, Q., Zhang, H., Zhai, Y., ... & Sun, A. (2023). Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma.

Tang, Z., Wang, L., Bajinka, O., Wu, G., & Tan, Y. (2022). Abnormal gene expression regulation mechanism of myeloid cell nuclear differentiation antigen in lung adenocarcinoma. Biology, 11(7), 1047.

Gu, L., Casserly, D., Brady, G., Carpenter, S., Bracken, A. P., Fitzgerald, K. A., ... & Bowie, A. G. (2022). Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7. Nature Communications, 13(1), 14.

Righi, S., Novero, D., Godio, L., Bertuzzi, C., Bacci, F., Agostinelli, C., ... & Sabattini, E. (2022). Myeloid nuclear differentiation antigen: an aid in differentiating lymphoplasmacytic lymphoma and splenic marginal zone lymphoma in bone marrow biopsies at presentation. Human Pathology, 124, 67-75.

Manohar, V., Peerani, R., Tan, B., Gratzinger, D., & Natkunam, Y. (2020). Myeloid cell nuclear differentiation antigen (MNDA) positivity in primary follicles: potential pitfall in the differential diagnosis with marginal zone lymphoma. Applied Immunohistochemistry & Molecular Morphology, 28(5), 384-388.

Wang, Z., & Cook, J. R. (2019). IRTA1 and MNDA expression in marginal zone lymphoma: utility in differential diagnosis and implications for classification. American journal of clinical pathology, 151(3), 337-343.

Ge, D., Chen, H., Zheng, S., Zhang, B., Ge, Y., Yang, L., & Cao, X. (2019). Hsa-miR-889-3p promotes the proliferation of osteosarcoma through inhibiting myeloid cell nuclear differentiation antigen expression. Biomedicine & Pharmacotherapy, 114, 108819.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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