MNDA

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
Full Name
Myeloid Cell Nuclear Differentiation Antigen
Function
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Biological Process
Activation of innate immune response Source: GO_Central
B cell receptor signaling pathway Source: UniProtKB
Cellular defense response Source: ProtInc
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to interferon-beta Source: GO_Central
Negative regulation of B cell proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
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Anti-MNDA antibodies

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Mouse Anti-MNDA (AA 311-408) Recombinant Antibody (CBFYM-2438) (CBMAB-M2625-FY)

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Target: MNDA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2438
Application*: E, P
Datasheet SDS

Rat Anti-MNDA Recombinant Antibody (3C1) (CBMAB-CP1568-LY)

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Target: MNDA
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C1
Application*: WB, IF (IC), F
Datasheet SDS

Mouse Anti-MNDA Recombinant Antibody (1H2) (CBMAB-A5538-LY)

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Target: MNDA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H2
Application*: IH, E
Datasheet SDS

Mouse Anti-MNDA Recombinant Antibody (CBFYM-2439) (CBMAB-M2626-FY)

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Target: MNDA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2439
Application*: IC, C
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Mouse Anti-MNDA (AA 37-321) Recombinant Antibody (CBFYM-2437) (CBMAB-M2624-FY)

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Target: MNDA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2437
Application*: WB, IH
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Mouse Anti-MNDA Recombinant Antibody (CBFYM-0701) (CBMAB-M0837-FY)

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Target: MNDA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0701
Application*: E, IC, IF, IH
Datasheet SDS

Mouse Anti-MNDA Recombinant Antibody (CBFYM-0426) (CBMAB-M0540-FY)

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Target: MNDA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0426
Application*: IF, F, C, P
Datasheet SDS

Rat Anti-MNDA Recombinant Antibody (CBFYM-0133) (CBMAB-M0153-FY)

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Target: MNDA
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0133
Application*: WB, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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