Human MNDA ELISA Kit (V2LY-0626-LY585)

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Tested Data
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.01 ng/mL
Detection Range
0.02-6 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
45.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Myeloid Cell Nuclear Differentiation Antigen
Function
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Biological Process
Activation of innate immune response Source: GO_Central
B cell receptor signaling pathway Source: UniProtKB
Cellular defense response Source: ProtInc
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to interferon-beta Source: GO_Central
Negative regulation of B cell proliferation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

Gupta, N., Roychoudry, S., Sticco, K. L., Hsu, P., Zhang, X., & Sheikh-Fayyaz, S. (2023). Study of the Utility of Myeloid Cell Nuclear Differentiation Antigen (MNDA) in the Diagnosis of Marginal Zone Lymphoma. Applied Immunohistochemistry & Molecular Morphology, 31(4), 217.

Meng, Y., Zhang, M., Li, X., Dong, Q., Zhang, H., Zhai, Y., ... & Sun, A. (2023). Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma.

Tang, Z., Wang, L., Bajinka, O., Wu, G., & Tan, Y. (2022). Abnormal gene expression regulation mechanism of myeloid cell nuclear differentiation antigen in lung adenocarcinoma. Biology, 11(7), 1047.

Gu, L., Casserly, D., Brady, G., Carpenter, S., Bracken, A. P., Fitzgerald, K. A., ... & Bowie, A. G. (2022). Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7. Nature Communications, 13(1), 14.

Righi, S., Novero, D., Godio, L., Bertuzzi, C., Bacci, F., Agostinelli, C., ... & Sabattini, E. (2022). Myeloid nuclear differentiation antigen: an aid in differentiating lymphoplasmacytic lymphoma and splenic marginal zone lymphoma in bone marrow biopsies at presentation. Human Pathology, 124, 67-75.

Manohar, V., Peerani, R., Tan, B., Gratzinger, D., & Natkunam, Y. (2020). Myeloid cell nuclear differentiation antigen (MNDA) positivity in primary follicles: potential pitfall in the differential diagnosis with marginal zone lymphoma. Applied Immunohistochemistry & Molecular Morphology, 28(5), 384-388.

Wang, Z., & Cook, J. R. (2019). IRTA1 and MNDA expression in marginal zone lymphoma: utility in differential diagnosis and implications for classification. American journal of clinical pathology, 151(3), 337-343.

Ge, D., Chen, H., Zheng, S., Zhang, B., Ge, Y., Yang, L., & Cao, X. (2019). Hsa-miR-889-3p promotes the proliferation of osteosarcoma through inhibiting myeloid cell nuclear differentiation antigen expression. Biomedicine & Pharmacotherapy, 114, 108819.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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