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Mouse Anti-MOB1B Recombinant Antibody (2F8) (CBMAB-A5541-LY)

The product is antibody recognizes MOBKL1A. The antibody 2F8 immunoassay techniques such as: IF, ELISA.
See all MOB1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F8
Antibody Isotype
IgG1, κ
Application
IF, ELISA

Basic Information

Immunogen
MOBKL1A (NP_775739.1, 120 a.a. ~ 216 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MOB KINASE ACTIVATOR 1B
Introduction
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. [provided by RefSeq]
Entrez Gene ID
92597
UniProt ID
Q7L9L4
Alternative Names
MATS2; MGC33910; MOB4A; Mob1B
Function
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Biological Process
Hippo signaling Source: UniProtKB
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of protein autophosphorylation Source: UniProtKB
Signal transduction Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
PTM
Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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