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Mouse Anti-MPL Recombinant Antibody (CBYJT-1473) (CBMAB-T0504-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to MPL (MPL Proto-Oncogene, Thrombopoietin Receptor). The antibody can be used for immunoassay techniques, such as WB.
See all MPL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1473
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MPL Proto-Oncogene, Thrombopoietin Receptor
Introduction
MPL is a receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. MPL may represent a regulatory molecule specific for TPO-R-dependent immune responses.
Entrez Gene ID
4352
UniProt ID
P40238
Alternative Names
MPL Proto-Oncogene, Thrombopoietin Receptor; Myeloproliferative Leukemia Virus Oncogene; Myeloproliferative Leukemia Protein; Proto-Oncogene C-Mpl; TPO-R; TPOR; Thrombopoietin Receptor
Function
Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Biological Process
Basophil homeostasis Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cytokine-mediated signaling pathway Source: GO_Central
Eosinophil homeostasis Source: Ensembl
Hemopoiesis Source: GO_Central
Monocyte homeostasis Source: Ensembl
Neutrophil homeostasis Source: Ensembl
Platelet aggregation Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of lymphocyte proliferation Source: Ensembl
Positive regulation of platelet formation Source: Ensembl
Thrombopoietin-mediated signaling pathway Source: GO_Central
Cellular Location
Plasma membrane
Cell membrane
Golgi apparatus
Other locations
Cell surface
Involvement in disease
Congenital amegakaryocytic thrombocytopenia (CAMT):
Disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies.
Thrombocythemia 2 (THCYT2):
A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
Myelofibrosis with myeloid metaplasia (MMM):
A chronic myeloproliferative disorder characterized by replacement of the bone marrow by fibrous tissue, extramedullary hematopoiesis, anemia, leukoerythroblastosis and hepatosplenomegaly.
Topology
Extracellular: 26-491
Helical: 492-513
Cytoplasmic: 514-635
PTM
Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.

Al-Nakhle, H. H., Yagoub, H. S., Anbarkhan, S. H., Alamri, G. A., & Alsubaie, N. M. (2023). In Silico Evaluation of Coding and Non-Coding nsSNPs in the Thrombopoietin Receptor (MPL) Proto-Oncogene: Assessing Their Influence on Protein Stability, Structure, and Function. Current Issues in Molecular Biology, 45(12), 9390-9412.

Zoine, J. T., Prince, C., Story, J. Y., Branella, G. M., Lytle, A. M., Fedanov, A., ... & Chandrakasan, S. (2022). Thrombopoietin-based CAR-T cells demonstrate in vitro and in vivo cytotoxicity to MPL positive acute myelogenous leukemia and hematopoietic stem cells. Gene Therapy, 29(5), 1-12.

Spivak, J. L., & Moliterno, A. R. (2021). The thrombopoietin receptor, MPL, is a therapeutic target of opportunity in the MPN. Frontiers in Oncology, 11, 641613.

Guglielmelli, P., & Calabresi, L. (2021). The MPL mutation. International Review of Cell and Molecular Biology, 365, 163-178.

Cui, L., Moraga, I., Lerbs, T., Van Neste, C., Wilmes, S., Tsutsumi, N., ... & Wernig, G. (2021). Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors. Proceedings of the National Academy of Sciences, 118(2), e2017849118.

Elbager, S. G., Makkawi, A. A., Mohamed, H. A., Abdelrahman, F. A., Osman, L. H., Hameed, M. F., ... & Bayoumi, M. (2019). In silico analysis of Missense Variants in Human MPL Gene Associated with Essential Thrombocythemia. bioRxiv, 830372.

Kohlscheen, S., Schenk, F., Rommel, M. G., Cullmann, K., & Modlich, U. (2019). Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice. Blood, The Journal of the American Society of Hematology, 133(13), 1465-1478.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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