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Mouse Anti-MPP1 (AA 1-98) Recombinant Antibody (CBFYM-2506) (CBMAB-M2693-FY)

This product is mouse antibody that recognizes MPP1. The antibody CBFYM-2506 can be used for immunoassay techniques such as: ELISA, WB.
See all MPP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2506
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MTLKASEGES GGSMHTALSD LYLEHLLQKR SRPEAVSHPL NTVTEDMYTN GSPAPGSPAQ VKGQEVRKVR LIQFEKVTEE PMGITLKLNE KQSCTVAR
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-98

Target

Full Name
Membrane Palmitoylated Protein 1
Introduction
This gene encodes the prototype of the membrane-associated guanylate kinase family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
4354
UniProt ID
Q00013
Alternative Names
Membrane Palmitoylated Protein 1; Membrane Protein, Palmitoylated 1, 55kDa; Membrane Protein, Palmitoylated 1; DXS552E; EMP55; P55; Palmitoylated Erythrocyte Membrane Protein; Membrane Protein, Palmitoylated 1 (55kD); 55 KDa Erythrocyte Membrane Protein
Function
Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).
Biological Process
Regulation of neutrophil chemotaxis Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Plasma membrane
Cell membrane
Other locations
stereocilium
Note: Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with PALS1 in the retina, at the outer limiting membrane (OLM) (By similarity). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC) (By similarity). Colocalizes with NF2 in non-myelin-forming Schwann cells (PubMed:19144871).
PTM
Palmitoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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