Rabbit Anti-MRAS Recombinant Antibody (
18E11) (V2LY-0725-LY975)

Name: Rabbit Anti-MRAS Recombinant Antibody (18E11)
SKU: V2LY-0725-LY975
Rating: 5 (1 reviews)

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Tested Data

Rabbit Anti-MRAS Recombinant Antibody (18E11) (V2LY-0725-LY975) in WB

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, PC3 whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, HEK293 whole cell lysate
All lanes: MRAS antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 24, 16 kDa
Observed band size: 24 kDa

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

18E11

Application

ELISA, WB

Immunogen

A synthesized peptide derived from human MRAS.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MUSCLE RAS ONCOGENE HOMOLOG

Entrez Gene ID

22808

UniProt ID

O14807

Function

Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.

Biological Process

Actin cytoskeleton organization Source: ProtInc
Cellular response to leukemia inhibitory factor Source: Ensembl
Ras protein signal transduction Source: UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Noonan syndrome 11 (NS11):
A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS11 inheritance is autosomal dominant.

Shah, P. W., Reinberger, T., Hashmi, S., Aherrahrou, Z., & Erdmann, J. (2024). MRAS in coronary artery disease—Unchartered territory. IUBMB life.

Zhao, A., Li, D., Mao, X., Yang, M., Deng, W., Hu, W., ... & Li, L. (2022). GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling. Cell Death & Disease, 13(3), 260.

Zhou, D., Niu, Y., & Cui, X. S. (2020). M-RAS regulate CDH1 function in blastomere compaction during porcine embryonic development. Journal of Animal Reproduction and Biotechnology, 35(1), 12-20.

Endo, T. (2020). M-Ras is muscle-Ras, moderate-Ras, mineral-Ras, migration-Ras, and many more-Ras. Experimental Cell Research, 397(1), 112342.

Smith, S. B., Parisien, M., Bair, E., Belfer, I., Chabot-Doré, A. J., Gris, P., ... & Diatchenko, L. (2019). Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain, 160(3), 579.

Suzuki, H., Takenouchi, T., Uehara, T., Takasago, S., Ihara, S., Yoshihashi, H., & Kosaki, K. (2019). Severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant: a recurrent substitution in RAS homologs in various cancers. American Journal of Medical Genetics Part A, 179(8), 1628-1630.

Song, Y., Ma, R., & Zhang, H. (2019). The influence of MRAS gene variants on ischemic stroke and serum lipid levels in Chinese Han population. Medicine, 98(48).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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