Mouse Anti-MRAS Recombinant Antibody (CBFYM-2528) (CBMAB-M2715-FY)

This product is mouse antibody that recognizes MRAS. The antibody CBFYM-2528 can be used for immunoassay techniques such as: WB, FC, IF.
See all MRAS antibodies

Published Data

Fig.2 M-Ras induces JNK activation.

Fig.1 M-Ras induces JNK activation.

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-2528

Antibody Isotype

IgG2a

Application

WB, FC, IF

Basic Information

Immunogen

Full length human recombinant protein of human MRAS (NP_036351) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MUSCLE RAS ONCOGENE HOMOLOG

Introduction

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Entrez Gene ID

22808

UniProt ID

O14807

Alternative Names

Muscle RAS Oncogene Homolog; Ras-Related Protein R-Ras3; RRAS3; Muscle And Microspikes RAS; Ras-Related Protein M-Ras; R-RAS3; M-RAs

Function

Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.

Biological Process

Actin cytoskeleton organization Source: ProtInc
Cellular response to leukemia inhibitory factor Source: Ensembl
Ras protein signal transduction Source: UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Noonan syndrome 11 (NS11):
A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS11 inheritance is autosomal dominant.

References

Shah, P. W., Reinberger, T., Hashmi, S., Aherrahrou, Z., & Erdmann, J. (2024). MRAS in coronary artery disease—Unchartered territory. IUBMB life.

Zhao, A., Li, D., Mao, X., Yang, M., Deng, W., Hu, W., ... & Li, L. (2022). GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling. Cell Death & Disease, 13(3), 260.

Zhou, D., Niu, Y., & Cui, X. S. (2020). M-RAS regulate CDH1 function in blastomere compaction during porcine embryonic development. Journal of Animal Reproduction and Biotechnology, 35(1), 12-20.

Endo, T. (2020). M-Ras is muscle-Ras, moderate-Ras, mineral-Ras, migration-Ras, and many more-Ras. Experimental Cell Research, 397(1), 112342.

Smith, S. B., Parisien, M., Bair, E., Belfer, I., Chabot-Doré, A. J., Gris, P., ... & Diatchenko, L. (2019). Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain, 160(3), 579.

Suzuki, H., Takenouchi, T., Uehara, T., Takasago, S., Ihara, S., Yoshihashi, H., & Kosaki, K. (2019). Severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant: a recurrent substitution in RAS homologs in various cancers. American Journal of Medical Genetics Part A, 179(8), 1628-1630.

Song, Y., Ma, R., & Zhang, H. (2019). The influence of MRAS gene variants on ischemic stroke and serum lipid levels in Chinese Han population. Medicine, 98(48).

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-MRAS Recombinant Antibody (CBFYM-2528)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote

Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: