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Mouse Anti-MSC Recombinant Antibody (1D1) (CBMAB-A5601-LY)

The product is antibody recognizes MSC. The antibody 1D1 immunoassay techniques such as: WB, ELISA.
See all MSC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MSC (NP_005089.1, 103 a.a. ~ 188 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
musculin (activated B-cell factor-1)
Introduction
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq]
Entrez Gene ID
9242
UniProt ID
O60682
Alternative Names
ABF-1; ABF1; MYOR; bHLHa22
Function
Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.
Biological Process
Branchiomeric skeletal muscle development Source: Ensembl
Cardiac conduction system development Source: BHF-UCL
Cellular response to leukemia inhibitory factor Source: Ensembl
Developmental process Source: GO_Central
Diaphragm development Source: Ensembl
Regulation of transcription, DNA-templated Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal muscle tissue development Source: GO_Central
Cellular Location
Nucleus

Vanni, A., Carnasciali, A., Mazzoni, A., Russo, E., Farahvachi, P., Di Gloria, L., ... & Annunziato, F. (2023). Musculin does not modulate the disease course of Experimental Autoimmune Encephalomyelitis and DSS colitis. Immunology Letters, 255, 21-31.

Tang, Z., Gong, Z., & Sun, X. (2022). Long non-coding RNA musculin antisense RNA 1 promotes proliferation and suppresses apoptosis in osteoarthritic chondrocytes via the microRNA-369-3p/Janus kinase-2/signal transducers and activators of transcription 3 axis. Bioengineered, 13(1), 1554-1564.

Jin, X., Qiao, L., Fan, H., Liao, C., Zheng, J., Wang, W., ... & Zhao, W. (2021). Long non-coding RNA MSC-AS1 facilitates the proliferation and glycolysis of gastric cancer cells by regulating PFKFB3 expression. International journal of medical sciences, 18(2), 546.

Yan, J., Yu, J., Yuan, S., Tang, W., Ma, W., Yang, X., ... & Gao, W. (2021). Musculin is highly enriched in Th17 and IL‐22‐producing ILC3s and restrains pro‐inflammatory cytokines in murine colitis. European Journal of Immunology, 51(4), 995-998.

Yan, J., Yu, J., Liu, K., Liu, Y., Mao, C., & Gao, W. (2021). The pathogenic roles of IL-22 in colitis: its transcription regulation by musculin in T helper subsets and innate lymphoid cells. Frontiers in immunology, 12, 758730.

Li, S., Yang, S., Qiu, C., & Sun, D. (2021). LncRNA MSC-AS1 facilitates lung adenocarcinoma through sponging miR-33b-5p to up-regulate GPAM. Biochemistry and Cell Biology, 99(2), 241-248.

Yu, J., Liu, Y., Zhang, W., Yang, X., Tang, W., Liang, H., ... & Yan, J. (2020). Musculin deficiency aggravates colonic injury and inflammation in mice with inflammatory bowel disease. Inflammation, 43, 1455-1463.

Luchtel, R. A., Zimmermann, M. T., Hu, G., Dasari, S., Jiang, M., Oishi, N., ... & Feldman, A. L. (2019). Recurrent MSC E116K mutations in ALK-negative anaplastic large cell lymphoma. Blood, The Journal of the American Society of Hematology, 133(26), 2776-2789.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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