Mouse Anti-MSC (AA 1-100) Recombinant Antibody (CBFYM-2616) (CBMAB-M2804-FY)

Name: Mouse Anti-MSC (AA 1-100) Recombinant Antibody (CBFYM-2616)
SKU: CBMAB-M2804-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2616

Application

ELISA, WB

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MSTGSVSDPE EMELRGLQRE YPVPASKRPP LRGVERSYAS PSDNSSAEEE DPDGEEERCA LGTAGSAEGC KRKRPRVAGG GGAGGSAGGG GKKPLPAKGS

Specificity

Human

Antibody Isotype

IgG2b, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-100

More Infomation

Target

Full Name

musculin (activated B-cell factor-1)

Introduction

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.

Entrez Gene ID

9242

UniProt ID

O60682

Alternative Names

Musculin; Class A Basic Helix-Loop-Helix Protein 22; Activated B-Cell Factor-1; BHLHa22; ABF-1; ABF1

Function

Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.

Biological Process

Branchiomeric skeletal muscle development Source: Ensembl
Cardiac conduction system development Source: BHF-UCL
Cellular response to leukemia inhibitory factor Source: Ensembl
Developmental process Source: GO_Central
Diaphragm development Source: Ensembl
Regulation of transcription, DNA-templated Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Roof of mouth development Source: Ensembl
Skeletal muscle tissue development Source: GO_Central

Cellular Location

Nucleus

Vanni, A., Carnasciali, A., Mazzoni, A., Russo, E., Farahvachi, P., Di Gloria, L., ... & Annunziato, F. (2023). Musculin does not modulate the disease course of Experimental Autoimmune Encephalomyelitis and DSS colitis. Immunology Letters, 255, 21-31.

Tang, Z., Gong, Z., & Sun, X. (2022). Long non-coding RNA musculin antisense RNA 1 promotes proliferation and suppresses apoptosis in osteoarthritic chondrocytes via the microRNA-369-3p/Janus kinase-2/signal transducers and activators of transcription 3 axis. Bioengineered, 13(1), 1554-1564.

Jin, X., Qiao, L., Fan, H., Liao, C., Zheng, J., Wang, W., ... & Zhao, W. (2021). Long non-coding RNA MSC-AS1 facilitates the proliferation and glycolysis of gastric cancer cells by regulating PFKFB3 expression. International journal of medical sciences, 18(2), 546.

Yan, J., Yu, J., Yuan, S., Tang, W., Ma, W., Yang, X., ... & Gao, W. (2021). Musculin is highly enriched in Th17 and IL‐22‐producing ILC3s and restrains pro‐inflammatory cytokines in murine colitis. European Journal of Immunology, 51(4), 995-998.

Yan, J., Yu, J., Liu, K., Liu, Y., Mao, C., & Gao, W. (2021). The pathogenic roles of IL-22 in colitis: its transcription regulation by musculin in T helper subsets and innate lymphoid cells. Frontiers in immunology, 12, 758730.

Li, S., Yang, S., Qiu, C., & Sun, D. (2021). LncRNA MSC-AS1 facilitates lung adenocarcinoma through sponging miR-33b-5p to up-regulate GPAM. Biochemistry and Cell Biology, 99(2), 241-248.

Yu, J., Liu, Y., Zhang, W., Yang, X., Tang, W., Liang, H., ... & Yan, J. (2020). Musculin deficiency aggravates colonic injury and inflammation in mice with inflammatory bowel disease. Inflammation, 43, 1455-1463.

Luchtel, R. A., Zimmermann, M. T., Hu, G., Dasari, S., Jiang, M., Oishi, N., ... & Feldman, A. L. (2019). Recurrent MSC E116K mutations in ALK-negative anaplastic large cell lymphoma. Blood, The Journal of the American Society of Hematology, 133(26), 2776-2789.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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