Mouse Anti-MSI1 (AA 1-362) Recombinant Antibody (CBFYM-2631) (CBMAB-M2820-FY)

Name: Mouse Anti-MSI1 (AA 1-362) Recombinant Antibody (CBFYM-2631)
SKU: CBMAB-M2820-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2631

Application

Immunogen

E. coli-derived recombinant human Musashi-1, aa 1-362

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-362

More Infomation

Target

Full Name

Musashi RNA Binding Protein 1

Introduction

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.

Entrez Gene ID

4440

UniProt ID

O43347

Alternative Names

Musashi RNA Binding Protein 1; Musashi-1; RNA-Binding Protein Musashi Homolog 1; Musashi (Drosophila) Homolog 1; Musashi Homolog 1 (Drosophila); Musashi1

Function

RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U1-3AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).

Biological Process

Epithelial cell differentiation Source: Ensembl
Nervous system development Source: ProtInc
Response to hormone Source: Ensembl

Cellular Location

Cytoplasm
Nucleus

Darai, N., Mahalapbutr, P., Wolschann, P., Lee, V. S., Wolfinger, M. T., & Rungrotmongkol, T. (2022). Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein. Scientific Reports, 12(1), 12137.

Löblein, M. T., Falke, I., Eich, H. T., Greve, B., Götte, M., & Troschel, F. M. (2021). Dual knockdown of musashi RNA-binding proteins MSI-1 and MSI-2 attenuates putative cancer stem cell characteristics and therapy resistance in ovarian cancer cells. International Journal of Molecular Sciences, 22(21), 11502.

Chen, H., Liu, J., Wang, H., Cheng, Q., Zhou, C., Chen, X., & Ye, F. (2019). Inhibition of RNA-binding protein musashi-1 suppresses malignant properties and reverses paclitaxel resistance in ovarian carcinoma. Journal of Cancer, 10(6), 1580.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

MSI1 Matched Antibody Pair (757) (CAT#: APMAB-757LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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