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Mouse Anti-MT2A Recombinant Antibody (6G2) (CBMAB-A5644-LY)

The product is antibody recognizes MT2A. The antibody 6G2 immunoassay techniques such as: WB, ELISA.
See all MT2A antibodies
Published Data
Fig.1 The protein expression of metallothionein 2A (MT2A).
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Fig.2 Double immunocytochemical staining of HMBOX1 (green) and MT2A (red) showing agglomeration and co-localization in HUVECs.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
6G2
Antibody Isotype
IgG2a, λ
Application
WB, ELISA

Basic Information

Immunogen
MT2A (NP_005944.1, 1 a.a. ~ 61 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
metallothionein 2A
Entrez Gene ID
4502
UniProt ID
P02795
Alternative Names
MT2
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Biological Process
Cellular copper ion homeostasis Source: ProtInc
Cellular response to cadmium ion Source: GO_Central
Cellular response to copper ion Source: GO_Central
Cellular response to erythropoietin Source: UniProtKB
Cellular response to interleukin-3 Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Cellular zinc ion homeostasis Source: GO_Central
Detoxification of copper ion Source: GO_Central
Negative regulation of growth Source: UniProtKB
Cellular Location
Cytosol
Nucleus
Other locations
cytoplasm

Chen, R. F., Chen, P. M., Pan, C. S., Huang, C. C., & Chiang, E. P. I. (2023). Association of metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese. Scientific Reports, 13(1), 1292.

Wahyudi, L. D., Yu, S. H., & Cho, M. K. (2022). The effect of curcumin on the cadmium-induced mitochondrial apoptosis pathway by metallothionein 2A regulation. Life Sciences, 310, 121076.

Liu, X., Quan, J., Shen, Z., Zhang, Z., Chen, Z., Li, L., ... & Deng, X. (2022). Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer. Cancer Cell International, 22(1), 1-13.

Sung, H. C., Chang, K. S., Chen, S. T., Hsu, S. Y., Lin, Y. H., Hou, C. P., ... & Juang, H. H. (2022). Metallothionein 2A with Antioxidant and Antitumor Activity Is Upregulated by Caffeic Acid Phenethyl Ester in Human Bladder Carcinoma Cells. Antioxidants, 11(8), 1509.

Dias, A. M., de Mendonça, R. P., da Silva Kataoka, M. S., Jaeger, R. G., de Jesus Viana Pinheiro, J., & de Melo Alves Junior, S. (2022). Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells. Molecular biology reports, 49(5), 3665-3674.

Shimizu, M., Koma, Y. I., Sakamoto, H., Tsukamoto, S., Kitamura, Y., Urakami, S., ... & Yokozaki, H. (2021). Metallothionein 2A expression in cancer-associated fibroblasts and cancer cells promotes esophageal squamous cell carcinoma progression. Cancers, 13(18), 4552.

Sekovanić, A., Jurasović, J., & Piasek, M. (2020). Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans. Archives of Industrial Hygiene and Toxicology, 71(1), 27.

Wang, J., Huang, P., Zhao, W., Ren, W., Ai, L., & Wu, L. (2020). Quantitative assessment of the association of polymorphisms in the metallothionein 2A gene with cancer risk. Journal of International Medical Research, 48(8), 0300060520947937.

Shokrzadeh, M., Mohammadpour, A., Ghassemi-Barghi, N., Hoseini, V., Abediankenari, S., & Tabari, Y. S. (2019). Metallothionein-2A (rs1610216&rs28366003) gene polymorphisms and the risk of stomach adenocarcinoma. Arquivos de Gastroenterologia, 56, 367-371.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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