Human MT2A ELISA Kit (V2LY-0626-LY1638)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.093 ng/mL
Detection Range
0.2-70 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
6.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
metallothionein 2A
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Biological Process
Cellular copper ion homeostasis Source: ProtInc
Cellular response to cadmium ion Source: GO_Central
Cellular response to copper ion Source: GO_Central
Cellular response to erythropoietin Source: UniProtKB
Cellular response to interleukin-3 Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Cellular zinc ion homeostasis Source: GO_Central
Detoxification of copper ion Source: GO_Central
Negative regulation of growth Source: UniProtKB
Cellular Location
Cytosol
Nucleus
Other locations
cytoplasm

Chen, R. F., Chen, P. M., Pan, C. S., Huang, C. C., & Chiang, E. P. I. (2023). Association of metallothionein 2A rs10636 with low mean corpuscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese. Scientific Reports, 13(1), 1292.

Wahyudi, L. D., Yu, S. H., & Cho, M. K. (2022). The effect of curcumin on the cadmium-induced mitochondrial apoptosis pathway by metallothionein 2A regulation. Life Sciences, 310, 121076.

Liu, X., Quan, J., Shen, Z., Zhang, Z., Chen, Z., Li, L., ... & Deng, X. (2022). Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer. Cancer Cell International, 22(1), 1-13.

Sung, H. C., Chang, K. S., Chen, S. T., Hsu, S. Y., Lin, Y. H., Hou, C. P., ... & Juang, H. H. (2022). Metallothionein 2A with Antioxidant and Antitumor Activity Is Upregulated by Caffeic Acid Phenethyl Ester in Human Bladder Carcinoma Cells. Antioxidants, 11(8), 1509.

Dias, A. M., de Mendonça, R. P., da Silva Kataoka, M. S., Jaeger, R. G., de Jesus Viana Pinheiro, J., & de Melo Alves Junior, S. (2022). Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells. Molecular biology reports, 49(5), 3665-3674.

Shimizu, M., Koma, Y. I., Sakamoto, H., Tsukamoto, S., Kitamura, Y., Urakami, S., ... & Yokozaki, H. (2021). Metallothionein 2A expression in cancer-associated fibroblasts and cancer cells promotes esophageal squamous cell carcinoma progression. Cancers, 13(18), 4552.

Sekovanić, A., Jurasović, J., & Piasek, M. (2020). Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans. Archives of Industrial Hygiene and Toxicology, 71(1), 27.

Wang, J., Huang, P., Zhao, W., Ren, W., Ai, L., & Wu, L. (2020). Quantitative assessment of the association of polymorphisms in the metallothionein 2A gene with cancer risk. Journal of International Medical Research, 48(8), 0300060520947937.

Shokrzadeh, M., Mohammadpour, A., Ghassemi-Barghi, N., Hoseini, V., Abediankenari, S., & Tabari, Y. S. (2019). Metallothionein-2A (rs1610216&rs28366003) gene polymorphisms and the risk of stomach adenocarcinoma. Arquivos de Gastroenterologia, 56, 367-371.

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For research use only. Not intended for any clinical use.

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